Asialoglycoprotein receptor: Difference between revisions
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The '''asialoglycoprotein receptors''' are [[lectin]]s which bind [[asialoglycoprotein]] | The '''asialoglycoprotein receptors''' are [[lectin]]s which bind [[asialoglycoprotein]] and [[glycoprotein]]s from which a [[sialic acid]] has been removed to expose [[galactose]] residues. The receptors, which are located on [[liver cell]]s, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human [[carcinoma]] [[cell line]]s. [[Lactobionic acid]] has been used as a targeting moiety for [[drug delivery]] to cells expressing asialoglycoprotein receptors.<ref>{{cite journal | vauthors = Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K | title = Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity | journal = Auto- Immunity Highlights | volume = 3 | issue = 3 | pages = 119–25 | date = December 2012 | pmid = 26000135 | pmc = 4389076 | doi = 10.1007/s13317-012-0041-4 }}</ref> | ||
==External links== | == References == | ||
{{Reflist}} | |||
== External links == | |||
* {{MeshName|Asialoglycoprotein+receptor}} | * {{MeshName|Asialoglycoprotein+receptor}} | ||
Latest revision as of 16:31, 11 August 2018
| asialoglycoprotein receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | ASGR1 |
| Entrez | 432 |
| HUGO | 742 |
| OMIM | 108360 |
| RefSeq | NM_001671 |
| UniProt | P07306 |
| Other data | |
| Locus | Chr. 17 p13-p11 |
| asialoglycoprotein receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | ASGR2 |
| Entrez | 433 |
| HUGO | 743 |
| OMIM | 108361 |
| RefSeq | NM_080914 |
| UniProt | P07307 |
| Other data | |
| Locus | Chr. 17 p |
The asialoglycoprotein receptors are lectins which bind asialoglycoprotein and glycoproteins from which a sialic acid has been removed to expose galactose residues. The receptors, which are located on liver cells, remove the target glycoproteins from circulation. The asialoglycoprotein receptor has been demonstrated to have high expression on the surface of hepatocytes and several human carcinoma cell lines. Lactobionic acid has been used as a targeting moiety for drug delivery to cells expressing asialoglycoprotein receptors.[1]
References
- ↑ Roggenbuck D, Mytilinaiou MG, Lapin SV, Reinhold D, Conrad K (December 2012). "Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity". Auto- Immunity Highlights. 3 (3): 119–25. doi:10.1007/s13317-012-0041-4. PMC 4389076. PMID 26000135.
External links
- Asialoglycoprotein+receptor at the US National Library of Medicine Medical Subject Headings (MeSH)
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