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| {{Infobox_Disease |
| | #REDIRECT [[Antithrombin III deficiency]] |
| Name = {{PAGENAME}} |
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| Image = |
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| Caption = |
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| DiseasesDB = 783 |
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| ICD10 = |
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| ICD9 = {{ICD9|289.81}} |
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| ICDO = |
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| OMIM = 107300 |
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| MedlinePlus = |
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| eMedicineSubj = ped |
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| eMedicineTopic = 119 |
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| MeshID = D020152 |
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| }}
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| {{SI}}
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| {{CMG}}; {{AE}} {{MKA}} {{S.G.}}
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| ===Overview===
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| '''Antithrombin III deficiency''' is a [[rare disease|rare]] [[hereditary disorder]] that generally comes to light when a patient suffers recurrent venous [[thrombosis]] and [[pulmonary embolism]].
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| This was first described by Egeberg in 1965.<ref>Egeberg O. ''Inherited antithrombin deficiency causing thrombophilia.'' Thromb Diath Haemorrh 1965;13:516–520. PMID 14347873.</ref>
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| The patients are treated with [[anticoagulant]]s or, more rarely, with antithrombin concentrate.
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| In [[renal failure]], especially [[nephrotic syndrome]], antithrombin is lost in the urine, leading to a higher activity of [[Factor II]] and [[Factor X]] and in increased tendency to [[thrombosis]].
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| ==Differentiating antithrombin deficiency from other Diseases==
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| Antithrombin deficiency must be differentiated from other diseases that cause symptoms of DVT and pulmonary embolism such as: | |
| *Factor V Leiden mutation
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| *Protein C deficiency
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| *Protein S deficiency
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| *Prothrombin gene mutation
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| *Disseminated intravascular coagulation (DIC)
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| *Antiphospholipid antibody syndrome
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| For more information on differentiating antithrombin deficiency, [[Thrombophilia differential diagnosis|click here]].
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| ==See also==
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| * [[Antithrombin]]
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| ==References==
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| <references/>
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| ==External links==
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| * [http://www.med.uiuc.edu/hematology/PtAntithrombin.htm Patient's pages on antithrombin]
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| {{Hematology}}
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| [[pt:Deficiência de antitrombina III]]
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| [[CME Category::Cardiology]]
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| [[Category:Hematology]]
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| [[Category:Cardiology]]
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