Ankylosing spondylitis (patient information): Difference between revisions

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{{CMG}};  Jinhui Wu, MD
{{CMG}};  Jinhui Wu, MD
'''Associate Editor-In-Chief''': [[User:Ujjwal Rastogi|Ujjwal Rastogi, MBBS]] [mailto:urastogi@perfuse.org]


{{EJ}}


==Overview==
==Overview==
Ankylosing spondylitis is a chronic disease that causes inflammation of the joints between the spinal bones, and the joints between the spine and pelvis. Researches demonstrate HLA-B27, ARTS1 and IL23R  gene,may be associated with this disease. Usual symptoms include chronic [[pain]] in the lower back and hips, [[stiffness]] in the lower back or hip area, [[joint pain]], [[joint swelling]]. With disease progresses, patinets may show damages outside joints and spine, such as eye inflammation or [[uveitis]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Test on HLA-B27 gene and images of spine and joints may help diagnose ankylosing spondylitis. Treatments include [[medication]]s, [[surgery]] and [[physical therapy]]. Many patients with ankylosing spondylitis go well after treatment.
Ankylosing spondylitis is a chronic disease that causes inflammation of the joints between the spinal bones, and the joints between the spine and pelvis. Researches demonstrate HLA-B27, ARTS1 and IL23R  gene,may be associated with this disease. Usual symptoms include chronic [[pain]] in the lower back and hips, [[stiffness]] in the lower back or hip area, [[joint pain]], [[joint swelling]]. With disease progresses, patinets may show damages outside joints and spine, such as eye inflammation or [[uveitis]], [[fatigue]], [[loss of appetite]] and [[weight loss]]. Test on HLA-B27 gene and images of spine and joints may help diagnose ankylosing spondylitis. Treatments include [[medication]]s, [[surgery]] and [[physical therapy]]. Many patients with ankylosing spondylitis go well after treatment.


==How do I know if I have ankylosing spondylitis and what are the symptoms of ankylosing spondylitis?==
==What are the symptoms of ankylosing spondylitis?==
Early signs and symptoms of ankylosing spondylitis may limit in your back and hip. When the disease developes, other organs may be involved.
Early signs and symptoms of ankylosing spondylitis may limit in your back and hip. When the disease developes, other organs may be involved.
:*Chronic [[pain]] in your lower back and hips, [[stiffness]] in your lower back or hip area, especially in the morning and after periods of inactivity. With disease progresses, your symptoms get worse and you may feel [[pain]] and [[stiffness]] over time.  
:*Chronic [[pain]] in your lower back and hips, [[stiffness]] in your lower back or hip area, especially in the morning and after periods of inactivity. With disease progresses, your symptoms get worse and you may feel [[pain]] and [[stiffness]] over time.  
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:*Age: 10~40 years old.
:*Age: 10~40 years old.


==How to know you have ankylosing spondylitis?==
==When to seek urgent medical care?==
Call your health care provider if symptoms of ankylosing spondylitis develop.
 
==Treatment options==
[[Image:Morbus Bechterew.jpg|left|thumb|200px|Ankylosing spondylitis (Morbus Bechterew)]]
[[Image:Morbus Bechterew.jpg|left|thumb|200px|Ankylosing spondylitis (Morbus Bechterew)]]


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:*[[X-ray]]s, [[CT]] or [[MRI]] in spine and joints: These images allow the doctor to trace the changes in your spine, joints and bones, then modify your treatments.
:*[[X-ray]]s, [[CT]] or [[MRI]] in spine and joints: These images allow the doctor to trace the changes in your spine, joints and bones, then modify your treatments.


==When to seek urgent medical care?==
Call your health care provider if symptoms of ankylosing spondylitis develop.


==Treatment options==
*Meidcations
*Meidcations
:*[[Nonsteroidal anti-inflammatory drug]]s ([[NSAID]]s): NSAIDs may be used to control [[inflammation]] and [[pain]] in patients with ankylosing spondylitis. Usual drugs include [[ibuprofen]], [[naproxen]] and [[indomethacin]]. Usual [[side effect]]s are [[pain]], [[bleeding]] and [[ulcer]]s in upper gastrointestinal tract.
:*[[Nonsteroidal anti-inflammatory drug]]s ([[NSAID]]s): NSAIDs may be used to control [[inflammation]] and [[pain]] in patients with ankylosing spondylitis. Usual drugs include [[ibuprofen]], [[naproxen]] and [[indomethacin]]. Usual [[side effect]]s are [[pain]], [[bleeding]] and [[ulcer]]s in upper gastrointestinal tract.
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:*Whether the patient is got physical therapy.
:*Whether the patient is got physical therapy.


==Copyleft Sources==
==Sources==
http://www.nlm.nih.gov/medlineplus/ency/article/000420.htm
http://www.nlm.nih.gov/medlineplus/ency/article/000420.htm



Revision as of 19:58, 27 July 2011

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Jinhui Wu, MD Associate Editor-In-Chief: Ujjwal Rastogi, MBBS [2]


Overview

Ankylosing spondylitis is a chronic disease that causes inflammation of the joints between the spinal bones, and the joints between the spine and pelvis. Researches demonstrate HLA-B27, ARTS1 and IL23R gene,may be associated with this disease. Usual symptoms include chronic pain in the lower back and hips, stiffness in the lower back or hip area, joint pain, joint swelling. With disease progresses, patinets may show damages outside joints and spine, such as eye inflammation or uveitis, fatigue, loss of appetite and weight loss. Test on HLA-B27 gene and images of spine and joints may help diagnose ankylosing spondylitis. Treatments include medications, surgery and physical therapy. Many patients with ankylosing spondylitis go well after treatment.

What are the symptoms of ankylosing spondylitis?

Early signs and symptoms of ankylosing spondylitis may limit in your back and hip. When the disease developes, other organs may be involved.

Who is at risk for ankylosing spondylitis?

The cause of ankylosing spondylitis is not clear. Researches demonstrate the following factors may be associated with this disease.

  • Heredity: Almost 90% of patients with ankylosing spondylitis are born with the HLA-B27 gene. Recent data demonstrate gene ARTS1 and IL23R are associated with ankylosing spondylitis.
  • Gender: Male
  • Age: 10~40 years old.

When to seek urgent medical care?

Call your health care provider if symptoms of ankylosing spondylitis develop.

Treatment options

Ankylosing spondylitis (Morbus Bechterew)
  • HLA-B27 gene examinaton: Absence of gene HLA-B27 may suggest that you have less probobility to have ankylosing spondylitis.
  • Erythrocyte sedimentation rate (ESR): As an autoimmune disease, ESR my elevate in patients with ankylosing spondylitis.
  • C-reactive protein (CRP): CRP is a protein that your liver produces when the immune is damaged. CRP my elevate in patients with ankylosing spondylitis.
  • Complete blood count (CBC): Patients may demonstrate anemia, a complication that can result from the chronic inflammation of ankylosing spondylitis.
  • X-rays, CT or MRI in spine and joints: These images allow the doctor to trace the changes in your spine, joints and bones, then modify your treatments.


  • Meidcations
  • Surgery: Most patients with ankylosing spondylitis do not need surgery. Surgery is only recommended for those who suffers severe pain or joint damage.
  • Physical therapy: The purpose of physical therapy is to relieve pain and improved physical strength and flexibility. The therapist can treat you by hands or by assistive devices. Common therapies for patients with ankylosing spondylitis include:
  • Keep a proper posture
  • Range-of-motion and stretching exercises
  • Specific breathing exercises
  • Abdominal and back exercises

Diseases with similar symptoms

Where to find medical care for ankylosing spondylitis?

Directions to Hospitals Treating ankylosing spondylitis

Prevention of ankylosing spondylitis

Prevention of ankylosing spondylitis is not clear.

What to expect (Outlook/Prognosis)?

Prognosis of ankylosing spondylitis varies from person to person. Most patients can maintain a good function. Wwhile other patients may lose daily functions. Prognosis depends on:

  • Onset age: The early onset age, the worse prognosis will be.
  • Whether organs outside joints are affected.
  • Whether the patient is treated in time.
  • Whether the patient is got physical therapy.

Sources

http://www.nlm.nih.gov/medlineplus/ency/article/000420.htm


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