Angiomyolipoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]

Overview

CT guided biopsy is diagnostic of angiomyolipoma.

Biopsy findings of angiomyolipoma include:

Microscopic features of angiomyolipoma are:

Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[2]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[2]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.^[2]
Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. HMB-45 immunostain.^[2]

Cytologic features of angiomyolipoma include:^[1]

Immunohistochemistry markers of angiomyolipoma include:

Melanocytic markers positive^[3]
- HMB-45 positive in all cases (15/15)^[4]
- Melan A positive in ~87% of cases (13/15)
Epithelial markers negative^[3]
- EMA
- AE1/AE3
SMA positive
CD117 positive/negative
Ki-67:^[5]
- Epithelioid variant of angiomyolipoma positive
- Conventional angiomyolipoma negative

↑ ^1.0 ^1.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter |month= ignored (help)
↑ ^2.0 ^2.1 ^2.2 ^2.3 http://librepathology.org/wiki/index.php/Angiomyolipoma
↑ ^3.0 ^3.1 Template:Ref GUP
↑ Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter |month= ignored (help)
↑ Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.