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| {{Drugbox
| | #REDIRECT [[Ampicillin-Sulbactam]] |
| | type = combo
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| | component1 = Ampicillin
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| | class1 = [[Penicillin]] [[antibiotic]]
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| | component2 = Sulbactam
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| | class2 = [[Beta-lactamase inhibitor]]
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| | CAS_number =
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| | ATC_prefix = J01
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| | ATC_suffix = CR01
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| | PubChem = 656676
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| | DrugBank =
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = <!-- A / B / C / D / X -->
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| | pregnancy_category=
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| | legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
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| | legal_CA = <!-- / Schedule I, II, III, IV, V, VI, VII, VIII -->
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| | legal_UK = <!-- GSL / P / POM / CD / Class A, B, C -->
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| | legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V -->
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| | legal_status =
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| | routes_of_administration =
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| }}
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| {{SI}}
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| '''Ampicillin/sulbactam''' is a combination of the common [[penicillin]]-derived [[antibiotic]] [[ampicillin]] and [[sulbactam]], an [[Enzyme inhibitor|inhibitor]] of [[bacteria]]l [[beta-lactamase]]. Two different forms of the drug exist. The first, developed in [[1987]] and marketed in the United States under the tradename '''Unasyn''', is an [[intravenous]] antibiotic. The second, an oral form called [[sultamicillin]], is marketed under the trade name '''Ampictam''' outside of the United States. Ampicillin/sulbactam is used to treat [[infection]]s caused by bacteria resistant to [[beta-lactam antibiotic]]s. Sulbactam blocks the [[enzyme]] which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria.
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| {| class="wikitable" style="text-align:center"
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| | [[Image:Ampicillin-2D-skeletal.png|200px]] || [[Image:Sulbactam.svg|100px]] || [[Image:Sultamicillin schematic.svg|220px]]
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| |-
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| | [[Skeletal formula]] of [[ampicillin]] || Skeletal formula of [[sulbactam]] || Skeletal formula of [[sultamicillin]], highlighting ampicillin in blue and sulbactam in orange
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| |}
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| Ampicillin/sulbactam is also used when the cause of an infection is not known ([[empiric therapy]]). [[peritonitis|Intra-abdominal infections]], skin infections, [[pneumonia]], and [[gynecology|gynecologic infections]]. It is active against a wide range of bacterial groups, including ''[[Staphylococcus aureus]]'', ''[[Enterobacteriaceae]]'', and [[anaerobic bacteria]]. Importantly, it is not active against ''[[Pseudomonas aeruginosa]]'' and should not be used alone when infection with this organism is suspected or known.
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| {{PenicillinAntiBiotics}}
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| [[Category: Beta-lactam antibiotics]]
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| [[Category:Combination antibiotics]]
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| {{WS}}
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