Aminoglutethimide

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Aminoglutethimide
Aminoglutethimide.svg
Clinical data
Pregnancy
category
Routes of
administration
Oral
ATC code
Pharmacokinetic data
Bioavailability>95%
MetabolismHepatic
Elimination half-life12.5 ± 1.6 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
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Chemical and physical data
FormulaC13H16N2O2
Molar mass232.278 g/mol

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Aminoglutethimide blocks the conversion of cholesterol to pregnenolone by inhibiting the enzyme desmolase, thus inhibits synthesis of all hormonally active steroids. It can be used in conjunction with other drugs for treatment of steroid-producing adrenocortical cancer.

Its major side effects are liver toxicity, inhibition of cortisol in the human body, and it may also cause hypothyroidism. Since cortisol helps break down muscle, aminoglutethimide is used by bodybuilders in a steroid cycle.

It is still used to suppress corticosteroid production in Cushing's Syndrome.

See also

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