Aggressive NK-cell leukemia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [5]

Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3

Overview

Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course.[1][2][3]

Historical Perspective

  • Aggressive NK-cell leukemia was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].

Classification

  • There is no classification system for aggressive NK-cell leukemia.

Pathophysiology

  • The pathogenesis of aggressive NK-cell leukemia is characterized by:
  • The XXXX has been associated with the development of aggressive NK-cell leukemia, involving the [molecular pathway] pathway.
  • On gross pathology, characteristic findings of aggressive NK-cell leukemia, include:
  • On microscopic histopathological analysis, characteristic findings of aggressive NK-cell leukemia, include:

Causes

  • There are no established causes for aggressive NK-cell leukemia.

Differentiating Aggressive NK-cell Leukemia from Other Diseases

  • Aggressive NK-cell leukemia must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
  • [Differential dx1]
  • [Differential dx2]
  • [Differential dx3]

Epidemiology and Demographics

  • The prevalence of aggressive NK-cell leukemia is approximately [number or range] per 100,000 individuals worldwide.
  • In [year], the incidence of aggressive NK-cell leukemia was estimated to be [number or range] cases per 100,000 individuals in [location].

Age

  • Patients of all age groups may develop aggressive NK-cell leukemia.
  • Aggressive NK-cell leukemia is more commonly observed among patients aged [age range] years old.
  • Aggressive NK-cell leukemia is more commonly observed among [elderly patients/young patients/children].

Gender

  • Aggressive NK-cell leukemia affects men and women equally.
  • [Gender 1] are more commonly affected with aggressive NK-cell leukemia than [gender 2].
  • The [gender 1] to [Gender 2] ratio is approximately [number > 1] to 1.

Race

  • There is no racial predilection for aggressive NK-cell leukemia.
  • Aggressive NK-cell leukemia usually affects individuals of the [race 1] race.
  • [Race 2] individuals are less likely to develop aggressive NK-cell leukemia.

Risk Factors

  • Common risk factors in the development of aggressive NK-cell leukemia, include:

Natural History, Complications and Prognosis

  • The majority of patients with aggressive NK-cell leukemia are symptomatic at diagnosis.
  • Early clinical features include
  • If left untreated, patients with aggressive NK-cell leukemia may progress to develop
  • Common complications of aggressive NK-cell leukemia include [complication 1], [complication 2], and [complication 3].
  • Prognosis is generally poor, and the median survival rate of patients with aggressive NK-cell leukemia is approximately 12 months.

Diagnosis

Symptoms

  • Aggressive NK-cell leukemia is usually asymptomatic.
  • Symptoms of aggressive NK-cell leukemia may include the following:
  • [symptom 1]
  • [symptom 2]
  • [symptom 3]
  • [symptom 4]
  • [symptom 5]
  • [symptom 6]

Physical Examination

  • Patients with aggressive NK-cell leukemia usually appear [general appearance].
  • Physical examination may be remarkable for:
  • [finding 1]
  • [finding 2]
  • [finding 3]
  • [finding 4]
  • [finding 5]
  • [finding 6]

Laboratory Findings

  • Laboratory findings consistent with the diagnosis of aggressive NK-cell leukemia, include:

Imaging Findings

  • [Imaging study 1] is the imaging modality of choice for aggressive NK-cell leukemia.
  • On [imaging study 1], aggressive NK-cell leukemia is characterized by [finding 1], [finding 2], and [finding 3].
  • [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

  • Aggressive NK-cell leukemia may also be diagnosed using
  • Findings on [diagnostic study name] include [finding 1], [finding 2], and [finding 3].

Treatment

Medical Therapy

  • The mainstay of therapy for aggressive NK-cell leukemia is [medical therapy 1] and [medical therapy 2].

Surgery

  • Surgery is not recommended among patients with aggressive NK-cell leukemia.


Prevention

  • There are no primary preventive measures available for aggressive NK-cell leukemia.


References

  1. [1] Chan JK, Sin VC, Wong KF, Ng CS, Tsang WY, Chan CH, Cheung MM, Lau WH. "Nonnasal lymphoma expressing the natural killer cell marker CD56: a clinicopathologic study of 49 cases of an uncommon aggressive neoplasm." Blood. 1997 Jun 15;89(12):4501-13. PMID 9192774
  2. [2] Imamura N, Kusunoki Y, Kawa-Ha K, Yumura K, Hara J, Oda K, Abe K, Dohy H, Inada T, Kajihara H, et al. "Aggressive natural killer cell leukaemia/lymphoma: report of four cases and review of the literature. Possible existence of a new clinical entity originating from the third lineage of lymphoid cells." Br J Haematol. 1990 May;75(1):49-59. PMID 2375924
  3. [3] Chan JK. "Natural killer cell neoplasms." Anat Pathol. 1998;3:77-145. PMID 10389582