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'''Acute megakaryoblastic leukemia''' (AMKL) is a form of [[leukemia]] where a majority of the blasts are [[megakaryoblastic]].<ref name="titleFinal Diagnosis -- Case 439">{{cite web |url=http://path.upmc.edu/cases/case439/dx.html |title=Final Diagnosis -- Case 439 |accessdate=2008-03-08 |format= |work=}}</ref>
'''Acute megakaryoblastic leukemia''' (AMKL) is a form of [[leukemia]] where a majority of the blasts are [[megakaryoblastic]].<ref name="titleFinal Diagnosis -- Case 439">{{cite web |url=http://path.upmc.edu/cases/case439/dx.html |title=Final Diagnosis -- Case 439 |accessdate=2008-03-08 |format= |work=}}</ref>


It is classified under [[Acute_myelogenous_leukemia#French-American-British_classification|M7]] in the [[French-American-British classification]].<ref name="urlAcute Myeloid Leukemia - Signs and Symptoms">{{cite web |url=http://www.ucsfhealth.org/adult/medical_services/cancer/leukemia/conditions/aml/signs.html |title=Acute Myeloid Leukemia - Signs and Symptoms |format= |work=}}</ref>
This rare subtype of AML was first reported in 1931 by Von Boros and his colleagues.<ref name="OkiKantarjian2006">{{cite journal|last1=Oki|first1=Yasuhiro|last2=Kantarjian|first2=Hagop M.|last3=Zhou|first3=Xian|last4=Cortes|first4=Jorge|last5=Faderl|first5=Stefan|last6=Verstovsek|first6=Srdan|last7=O'Brien|first7=Susan|last8=Koller|first8=Charles|last9=Beran|first9=Miloslav|last10=Bekele|first10=B. Nebiyou|last11=Pierce|first11=Sherry|last12=Thomas|first12=Deborah|last13=Ravandi|first13=Farhad|last14=Wierda|first14=William G.|last15=Giles|first15=Francis|last16=Ferrajoli|first16=Alessandra|last17=Jabbour|first17=Elias|last18=Keating|first18=Michael J.|last19=Bueso-Ramos|first19=Carlos E.|last20=Estey|first20=Elihu|last21=Garcia-Manero|first21=Guillermo|title=Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center|journal=Blood|volume=107|issue=3|year=2006|pages=880–884|issn=0006-4971|doi=10.1182/blood-2005-06-2450}}</ref>
 
It is classified under [[Acute_myelogenous_leukemia#French-American-British_classification|M7]] in the [[French-American-British classification]].<ref name="Bennett1985">{{cite journal|last1=Bennett|first1=John M.|title=Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)|journal=Annals of Internal Medicine|volume=103|issue=3|year=1985|pages=460|issn=0003-4819|doi=10.7326/0003-4819-103-3-460}}</ref>


In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Downs syndrome.<ref>Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965. </ref>
In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Downs syndrome.<ref>Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965. </ref>

Revision as of 03:45, 16 April 2021

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acute megakaryoblastic leukemia (AMKL) is a form of leukemia where a majority of the blasts are megakaryoblastic.[1]

This rare subtype of AML was first reported in 1931 by Von Boros and his colleagues.[2]

It is classified under M7 in the French-American-British classification.[3]

In the first three years of life megakaryoblastic leukemia is the most common type of leukemia in patients with Downs syndrome.[4]

References

  1. "Final Diagnosis -- Case 439". Retrieved 2008-03-08.
  2. Oki, Yasuhiro; Kantarjian, Hagop M.; Zhou, Xian; Cortes, Jorge; Faderl, Stefan; Verstovsek, Srdan; O'Brien, Susan; Koller, Charles; Beran, Miloslav; Bekele, B. Nebiyou; Pierce, Sherry; Thomas, Deborah; Ravandi, Farhad; Wierda, William G.; Giles, Francis; Ferrajoli, Alessandra; Jabbour, Elias; Keating, Michael J.; Bueso-Ramos, Carlos E.; Estey, Elihu; Garcia-Manero, Guillermo (2006). "Adult acute megakaryocytic leukemia: an analysis of 37 patients treated at M.D. Anderson Cancer Center". Blood. 107 (3): 880–884. doi:10.1182/blood-2005-06-2450. ISSN 0006-4971.
  3. Bennett, John M. (1985). "Criteria for the Diagnosis of Acute Leukemia of Megakaryocyte Lineage (M7)". Annals of Internal Medicine. 103 (3): 460. doi:10.7326/0003-4819-103-3-460. ISSN 0003-4819.
  4. Hitzler JK. (2007) Acute megakaryoblastic leukemia in Down syndrome. Pediatr Blood Cancer. Dec;49(7 Suppl):1066-9. PMID: 17943965.

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