Acute liver failure classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

1) The 1993 classification defines It reflects the fact that the pace of disease evolution strongly influence prognosis. Underlying aetiology is the other significant determinant of outcome.

• Hyperacute as within 1 week,
• Acute as 8-28 days and
• Subacute as 4-12 weeks

2) Acute liver failure may be fulminant or subfulminant. Both the forms have poor prognosis

• Fulminant hepatic failure - Development of hepatic encephalopathy within 2 months after the onset of acute liver disease.
• Subfulminant hepatic failure - Development of hepatic encephalopathy within 2 months to 6 months after the onset of acute liver disease