Acromegaly historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]
Overview
Acromegaly was first described by DR. Johannes Wier in 1567. Dr. Verga reported a case of acromegaly in 1864 and it was a case of a patient with a disproportionate big face. Through 1877 to 1900s, many physicians reported cases of acromegaly. In 1970, Dr. Besser used bromocriptine in the treatment of acromegaly and it showed a remarkable improvement in the patients. In 1988, FDA approved for the octreotide as a treatment to acromegaly.
Historical Perspective
Discovery
- In 1567, Dr. Johannes Wier was the first to describe a case of a giant female patient. Dr. Wier described the course of acromegaly in this patient in his article. Dr. Wier mentioned that she was of normal stature then she began to increase in height and size at age of fourteen. However, she had a normal good life. Dr. Wier also linked between the acromegaly and amenorrhea in this patient.[1]
- In 1772, Dr. Nicolas Saucerotte reported a case which has a clinical presentation linked with acromegaly.[2]
- In 1864, Dr. Andrea Verga reported a case of acromegaly. Dr. Verga reported a patient whose disproportion big face.
- In 1877, Dr. Brigidi reported a case of an actor who presented with chronic bone deformities. On examination, Dr. Bridgi observed large pituitary gland and it was the first description of pituitary adenoma. Dr. Bridgi then linked between the pituitary adenoma and the acromegaly.
- In 1877, Dr. Henri Henrot also reported a case of acromegaly.
- In 1884, Dr. Fritsche and Theodor Klebs also reported a case of acromegaly with pituitary adenoma.
- In 1886, Dr. Pierre Marie named the disease as acromegaly. Dr. Marie reported a patient presented with hypertrophied extremities and he linked between this presentation and acromegaly.
Landmark Events in the Development of Treatment Strategies
- In the 1970s, bromocriptine, a dopamine agonist, was used by Dr. G. Michael Besser to treat acromegaly. Dr. Besser used bromocriptine on some patients and it showed a remarkable improvement in most of the patients. A reduction in the growth hormone was also observed.[3]
- In 1973, Dr. Roger Guillemin and Paul Brazeau discovered somatostatin which is a polypeptide inhibitor of the growth hormone.[4]
- In 1978, somatostatin analogs were developed by Dr. Wylie W. Vale. These somatostatin analogs provide the same inhibitory function and potency of somatostatin against acromegaly.[5]
- In 1982, another somatostatin analog called octreotide was developed by Dr. Wilfried Bauer and his team.Octreotide had a greater potency in inhibiting the growth hormone and it can resist degradation by the enzymes.[6]
- In 1988, FDA approved for the octreotide as a treatment to acromegaly.
- In 2001, growth hormone receptor antagonists were developed by Dr. John Kopchick. The drug named pegvisomant after that and it has been successful in the treatment of acromegaly. Pegvisomant can be used with additional medications in the treatment of acromegaly.[7] [8]
References
- ↑ de Herder WW (2016). "The History of Acromegaly". Neuroendocrinology. 103 (1): 7–17. doi:10.1159/000371808. PMID 25572320.
- ↑ Pearce JM (2006). "Nicolas Saucerotte: Acromegaly before Pierre Marie". J Hist Neurosci. 15 (3): 269–75. doi:10.1080/09647040500471764. PMID 16887764.
- ↑ Besser GM, Wass JA, Thorner MO (1978). "Acromegaly--results of long term treatment with bromocriptine". Acta Endocrinol Suppl (Copenh). 216: 187–98. PMID 347861.
- ↑ Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J; et al. (1973). "Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone". Science. 179 (4068): 77–9. PMID 4682131.
- ↑ Vale W, Rivier J, Ling N, Brown M (1978). "Biologic and immunologic activities and applications of somatostatin analogs". Metabolism. 27 (9 Suppl 1): 1391–401. PMID 210361.
- ↑ Bauer W, Briner U, Doepfner W, Haller R, Huguenin R, Marbach P; et al. (1982). "SMS 201-995: a very potent and selective octapeptide analogue of somatostatin with prolonged action". Life Sci. 31 (11): 1133–40. PMID 6128648.
- ↑ Kopchick JJ, Okada S (2001). "Growth hormone receptor antagonists: discovery and potential uses". Growth Horm IGF Res. 11 Suppl A: S103–9. PMID 11527080.
- ↑ Trainer PJ, Drake WM, Katznelson L, Freda PU, Herman-Bonert V, van der Lely AJ; et al. (2000). "Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant". N Engl J Med. 342 (16): 1171–7. doi:10.1056/NEJM200004203421604. PMID 10770982.