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{{Acromegaly}}
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==Overview==
==Overview==
[[Pituitary gland]] MRI may be helpful in the diagnosis of acromegaly as [[Pituitary adenoma|pituitary adenomas]] are the most common cause of acromegaly. Findings on MRI suggestive of acromegaly include enlarged pituitary gland and an [[adenoma]] that may extend to the [[Suprasellar|suprasellar region]]. [[Spine]] MRI also may be helpful in the diagnosis as it shows [[hypertrophy]] of the spinal ligaments.


==MRI==
==MRI==
After acromegaly has been diagnosed by measuring GH or IGF-I levels, a magnetic resonance imaging (MRI) scan of the pituitary is used to locate and detect the size of the tumor causing GH overproduction. MRI is the most sensitive imaging technique, but computerized tomography (CT) scans can be used if the patient should not have MRI. For example, people who have pacemakers or other types of implants containing metal should not have an MRI scan because MRI machines contain powerful magnets.
*Pituitary MRI may be helpful in the diagnosis of acromegaly. Findings on MRI suggestive of acromegaly include:<ref name="pmid21470998">{{cite journal| author=Famini P, Maya MM, Melmed S| title=Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients. | journal=J Clin Endocrinol Metab | year= 2011 | volume= 96 | issue= 6 | pages= 1633-41 | pmid=21470998 | doi=10.1210/jc.2011-0168 | pmc=3100749 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21470998  }}</ref>
If a head scan fails to detect a pituitary tumor, the physician should look for non-pituitary “ectopic” tumors in the chest, abdomen, or pelvis as the cause of excess GH. The presence of such tumors usually can be diagnosed by measuring GHRH in the blood and by a CT scan of possible tumor sites.
**[[Pituitary adenoma]] as it is the most common cause of acromegaly and 75% of the patients have [[Macroadenoma of the pituitary gland|macroadenoma]]. On MRI, enlarged pituitary gland with [[gadolinium]] uptake is observed and the [[adenoma]] may extend to the [[Suprasellar|suprasellar region.]] 
Rarely, a pituitary tumor secreting GH may be too tiny to detect even with a sensitive MRI scan.  
*[[Spine]] MRI may be helpful also in the diagnosis of acromegaly. Findings on MRI show hypertrophy of spinal ligaments and [[cartilaginous]] structures and features of [[osteoarthritis]].
*Joints MRI shows [[Ligamentous laxity|ligamentous]] and [[cartilaginous]] hypertrophy and [[crystal]] deposition.
==References==
==References==
{{reflist|2}}
{{Reflist|2}}
 
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[[Category:Disease]]
[[Category:Endocrinology]]
[[Category:Genetic disorders]]

Latest revision as of 20:49, 14 August 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Pituitary gland MRI may be helpful in the diagnosis of acromegaly as pituitary adenomas are the most common cause of acromegaly. Findings on MRI suggestive of acromegaly include enlarged pituitary gland and an adenoma that may extend to the suprasellar region. Spine MRI also may be helpful in the diagnosis as it shows hypertrophy of the spinal ligaments.

MRI

References

  1. Famini P, Maya MM, Melmed S (2011). "Pituitary magnetic resonance imaging for sellar and parasellar masses: ten-year experience in 2598 patients". J Clin Endocrinol Metab. 96 (6): 1633–41. doi:10.1210/jc.2011-0168. PMC 3100749. PMID 21470998.

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