Acoustic neuroma causes: Difference between revisions
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{{Acoustic neuroma}} | {{Acoustic neuroma}} | ||
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==Overview== | ==Overview== | ||
Numerous studies show the correlation between [[Neurofibromatosis type II|Neurofibromatosis type 2 (NF2)]] and acoustic neuroma. Other causes can include exposure to occupational noise and cellular telephone use. | |||
==Causes== | ==Causes== | ||
* | === '''Neurofibromatosis type 2''' === | ||
* [[Genetics|Genetic]] studies have linked both sporadic and [[Neurofibromatosis type II|NF2]]-associated acoustic neuromas to a single [[gene]], the NF2 [[gene]], located on [[chromosome 22]] band q11–13.1.<ref>{{Cite journal|last=Bradley Welling|first=D.|date=1998|title=Clinical Manifestations of Mutations in the Neurofibrornatosis Type 2 Gene in Vestibular Schwannornas (Acoustic Neurornas)|url=|journal=The Lezyngoscope|volume=|pages=|via=}}</ref><ref>{{Cite journal|last=SUGHRUE|first=MICHAEL E.|date=2011|title=Molecular biology of familial and sporadic vestibular schwannomas: implications for novel therapeutics|url=|journal=J Neurosurg|volume=114|pages=|via=}}</ref> | |||
=== '''Childhood Radiation''' === | |||
* Exposure to radiation in childhood can lead to the development of acoustic neuroma. | |||
* Acoustic neuroma, in this case, can occur after a long latency period.<ref>{{Cite journal|last=Schneider|first=Arthur B.|date=2007|title=Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck|url=|journal=Neuro-Oncoly Oxford Journal|volume=|pages=|via=}}</ref> | |||
=== '''Other Causes''' === | |||
'''Cellular Telephone Use''' | |||
* It is suspected that the long term use of cellular phones can also lead to the development of acoustic neuroma but this suspicion is not backed by any significant data. | |||
'''Occupational noise exposure''' | |||
* A small number of [[Epidemiology|epidemiologic]] studies of occupational noise exposure, based on self-report, have suggested an association with acoustic neuroma.<ref>{{Cite journal|last=Preston-Martin,|first=S.|date=1989|title=Noise trauma in the aetiology of acoustic neuromas in men in Los Angeles County, 1978-1985|url=|journal=Br. J. Cancer|volume=|pages=|via=}}</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Latest revision as of 17:01, 23 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]Sabawoon Mirwais, M.B.B.S, M.D.[3]
Overview
Numerous studies show the correlation between Neurofibromatosis type 2 (NF2) and acoustic neuroma. Other causes can include exposure to occupational noise and cellular telephone use.
Causes
Neurofibromatosis type 2
- Genetic studies have linked both sporadic and NF2-associated acoustic neuromas to a single gene, the NF2 gene, located on chromosome 22 band q11–13.1.[1][2]
Childhood Radiation
- Exposure to radiation in childhood can lead to the development of acoustic neuroma.
- Acoustic neuroma, in this case, can occur after a long latency period.[3]
Other Causes
Cellular Telephone Use
- It is suspected that the long term use of cellular phones can also lead to the development of acoustic neuroma but this suspicion is not backed by any significant data.
Occupational noise exposure
- A small number of epidemiologic studies of occupational noise exposure, based on self-report, have suggested an association with acoustic neuroma.[4]
References
- ↑ Bradley Welling, D. (1998). "Clinical Manifestations of Mutations in the Neurofibrornatosis Type 2 Gene in Vestibular Schwannornas (Acoustic Neurornas)". The Lezyngoscope.
- ↑ SUGHRUE, MICHAEL E. (2011). "Molecular biology of familial and sporadic vestibular schwannomas: implications for novel therapeutics". J Neurosurg. 114.
- ↑ Schneider, Arthur B. (2007). "Acoustic neuromas following childhood radiation treatment for benign conditions of the head and neck". Neuro-Oncoly Oxford Journal.
- ↑ Preston-Martin,, S. (1989). "Noise trauma in the aetiology of acoustic neuromas in men in Los Angeles County, 1978-1985". Br. J. Cancer.