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{{Infobox_gene}}
{{PBB_Controls
The human [[gene]] '''ATP6AP1''' encodes the S1 subunit of the [[enzyme]] '''V-type proton ATPase'''.<ref name="pmid8733135">{{cite journal | vauthors = Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M | title = Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci | journal = Hum Mol Genet | volume = 5 | issue = 5 | pages = 659–68 |date=Jun 1997 | pmid = 8733135 | pmc = | doi =10.1093/hmg/5.5.659  }}</ref><ref name="pmid8281148">{{cite journal | vauthors = Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A | title = Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection | journal = Hum Mol Genet | volume = 2 | issue = 11 | pages = 1865–9 |date=Feb 1994 | pmid = 8281148 | pmc =  | doi =10.1093/hmg/2.11.1865 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=537| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = ATPase, H+ transporting, lysosomal accessory protein 1
| HGNCid = 868
| Symbol = ATP6AP1
| AltSymbols =; 16A; ATP6IP1; ATP6S1; Ac45; CF2; MGC129781; VATPS1; XAP-3; XAP3
| OMIM = 300197
| ECnumber = 
| Homologene = 914
| MGIid = 109629
| GeneAtlas_image1 = PBB_GE_ATP6AP1_207809_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005104 |text = fibroblast growth factor receptor binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0008201 |text = heparin binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046933 |text = hydrogen ion transporting ATP synthase activity, rotational mechanism}} {{GNF_GO|id=GO:0046961 |text = hydrogen ion transporting ATPase activity, rotational mechanism}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005773 |text = vacuole}} {{GNF_GO|id=GO:0009986 |text = cell surface}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016469 |text = proton-transporting two-sector ATPase complex}}
| Process = {{GNF_GO|id=GO:0000060 |text = protein import into nucleus, translocation}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0008543 |text = fibroblast growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0015986 |text = ATP synthesis coupled proton transport}} {{GNF_GO|id=GO:0015992 |text = proton transport}} {{GNF_GO|id=GO:0030326 |text = embryonic limb morphogenesis}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0048260 |text = positive regulation of receptor mediated endocytosis}} {{GNF_GO|id=GO:0050677 |text = positive regulation of urothelial cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 537
    | Hs_Ensembl = ENSG00000071553
    | Hs_RefseqProtein = NP_001174
    | Hs_RefseqmRNA = NM_001183
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 153310178
    | Hs_GenLoc_end = 153318056
    | Hs_Uniprot = Q15904
    | Mm_EntrezGene = 54411
    | Mm_Ensembl = ENSMUSG00000019087
    | Mm_RefseqmRNA = XM_903723
    | Mm_RefseqProtein = XP_908816
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70549826
    | Mm_GenLoc_end = 70557410
    | Mm_Uniprot = Q3THZ3
  }}
}}
'''ATPase, H+ transporting, lysosomal accessory protein 1''', also known as '''ATP6AP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=537| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.<ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=537| accessdate = }}</ref>
| summary_text = This gene encodes a component of a multisubunit enzyme (1 [[Atomic mass unit|mDa]] MW) that mediates acidification of [[Eukaryote|eukaryotic]] intracellular [[organelle]]s. Vacuolar ATPase ([[V-ATPase]]) is composed of a cytosolic, V<sub>1</sub>, (site of the ATP catalytic site) and a transmembrane, V<sub>0</sub>, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, [[zymogen]] activation, and receptor-mediated [[endocytosis]]. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine [[secretory granule]]s.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ATP6AP1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Finbow ME, Harrison MA |title=The vacuolar H+-ATPase: a universal proton pump of eukaryotes. |journal=Biochem. J. |volume=324 ( Pt 3) |issue=  |pages= 697-712 |year= 1997 |pmid= 9210392 |doi=  }}
*{{cite journal  | vauthors=Finbow ME, Harrison MA |title=The vacuolar H+-ATPase: a universal proton pump of eukaryotes |journal=Biochem. J. |volume=324 |issue=  3|pages= 697–712 |year= 1997 |pmid= 9210392 |doi= 10.1042/bj3240697| pmc=1218484 }}
*{{cite journal  | author=Stevens TH, Forgac M |title=Structure, function and regulation of the vacuolar (H+)-ATPase. |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue=  |pages= 779-808 |year= 1998 |pmid= 9442887 |doi= 10.1146/annurev.cellbio.13.1.779 }}
*{{cite journal  | vauthors=Stevens TH, Forgac M |title=Structure, function and regulation of the vacuolar (H+)-ATPase |journal=Annu. Rev. Cell Dev. Biol. |volume=13 |issue=  |pages= 779–808 |year= 1998 |pmid= 9442887 |doi= 10.1146/annurev.cellbio.13.1.779 }}
*{{cite journal  | author=Nelson N, Harvey WR |title=Vacuolar and plasma membrane proton-adenosinetriphosphatases. |journal=Physiol. Rev. |volume=79 |issue= 2 |pages= 361-85 |year= 1999 |pmid= 10221984 |doi=  }}
*{{cite journal  | vauthors=Nelson N, Harvey WR |title=Vacuolar and plasma membrane proton-adenosinetriphosphatases |journal=Physiol. Rev. |volume=79 |issue= 2 |pages= 361–85 |year= 1999 |pmid= 10221984 |doi=  10.1152/physrev.1999.79.2.361}}
*{{cite journal  | author=Forgac M |title=Structure and properties of the vacuolar (H+)-ATPases. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12951-4 |year= 1999 |pmid= 10224039 |doi=  }}
*{{cite journal  | author=Forgac M |title=Structure and properties of the vacuolar (H+)-ATPases |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 12951–4 |year= 1999 |pmid= 10224039 |doi=10.1074/jbc.274.19.12951 }}
*{{cite journal  | author=Kane PM |title=Introduction: V-ATPases 1992-1998. |journal=J. Bioenerg. Biomembr. |volume=31 |issue= 1 |pages= 3-5 |year= 1999 |pmid= 10340843 |doi=  }}
*{{cite journal  | author=Kane PM |title=Introduction: V-ATPases 1992-1998 |journal=J. Bioenerg. Biomembr. |volume=31 |issue= 1 |pages= 3–5 |year= 1999 |pmid= 10340843 |doi=10.1023/A:1001884227654 }}
*{{cite journal  | author=Wieczorek H, Brown D, Grinstein S, ''et al.'' |title=Animal plasma membrane energization by proton-motive V-ATPases. |journal=Bioessays |volume=21 |issue= 8 |pages= 637-48 |year= 1999 |pmid= 10440860 |doi= 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W }}
*{{cite journal  | vauthors=Wieczorek H, Brown D, Grinstein S |title=Animal plasma membrane energization by proton-motive V-ATPases |journal=BioEssays |volume=21 |issue= 8 |pages= 637–48 |year= 1999 |pmid= 10440860 |doi= 10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W |display-authors=etal}}
*{{cite journal  | author=Yokoi H, Hadano S, Kogi M, ''et al.'' |title=Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection. |journal=Genomics |volume=20 |issue= 3 |pages= 404-11 |year= 1994 |pmid= 8034313 |doi= 10.1006/geno.1994.1194 }}
*{{cite journal  | vauthors=Yokoi H, Hadano S, Kogi M |title=Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection |journal=Genomics |volume=20 |issue= 3 |pages= 404–11 |year= 1994 |pmid= 8034313 |doi= 10.1006/geno.1994.1194 |display-authors=etal}}
*{{cite journal  | author=Sedlacek Z, Korn B, Konecki DS, ''et al.'' |title=Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection. |journal=Hum. Mol. Genet. |volume=2 |issue= 11 |pages= 1865-9 |year= 1994 |pmid= 8281148 |doi=  }}
*{{cite journal  | vauthors=Holthuis JC, Jansen EJ, Schoonderwoert VT |title=Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 484–91 |year= 1999 |pmid= 10336633 |doi=10.1046/j.1432-1327.1999.00396.x |display-authors=etal}}
*{{cite journal  | author=Chen EY, Zollo M, Mazzarella R, ''et al.'' |title=Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 659-68 |year= 1997 |pmid= 8733135 |doi= }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Holthuis JC, Jansen EJ, Schoonderwoert VT, ''et al.'' |title=Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary. |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 484-91 |year= 1999 |pmid= 10336633 |doi=  }}
*{{cite journal  | vauthors=Bagai S, Rubio E, Cheng JF |title=Fibroblast growth factor-10 is a mitogen for urothelial cells |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23828–37 |year= 2002 |pmid= 11923311 |doi= 10.1074/jbc.M201658200 |display-authors=etal}}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Hodi FS, Schmollinger JC, Soiffer RJ |title=ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6919–24 |year= 2002 |pmid= 11983866 |doi= 10.1073/pnas.102025999 | pmc=124504 |display-authors=etal}}
*{{cite journal  | author=Bagai S, Rubio E, Cheng JF, ''et al.'' |title=Fibroblast growth factor-10 is a mitogen for urothelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23828-37 |year= 2002 |pmid= 11923311 |doi= 10.1074/jbc.M201658200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hodi FS, Schmollinger JC, Soiffer RJ, ''et al.'' |title=ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6919-24 |year= 2002 |pmid= 11983866 |doi= 10.1073/pnas.102025999 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 22:34, 5 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.[1][2][3]

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V1, (site of the ATP catalytic site) and a transmembrane, V0, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.[3]

References

  1. ↑ Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M (Jun 1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum Mol Genet. 5 (5): 659–68. doi:10.1093/hmg/5.5.659. PMID 8733135.
  2. ↑ Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A (Feb 1994). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum Mol Genet. 2 (11): 1865–9. doi:10.1093/hmg/2.11.1865. PMID 8281148.
  3. ↑ 3.0 3.1 "Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1".

External links

Further reading



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