ATP12A

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

ATPase, H+/K+ transporting, nongastric, alpha polypeptide (also known as ATP12A) is a protein that in humans is encoded by the ATP12A gene.

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.

External links

• Human ATP12A genome location and ATP12A gene details page in the UCSC Genome Browser.

Further reading

• Modyanov NN, Petrukhin KE, Sverdlov VE, et al. (1991). "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase". FEBS Lett. 278 (1): 91–4. doi:10.1016/0014-5793(91)80091-G. PMID 1847115.
• Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
• Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
• Sverdlov ED, Monastyrskaya GS, Broude NE, et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
• Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN (1994). "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family". FEBS Lett. 349 (1): 144–50. doi:10.1016/0014-5793(94)00655-5. PMID 8045293.
• Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics. 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Pestov NB, Romanova LG, Korneenko TV, et al. (1999). "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit". FEBS Lett. 440 (3): 320–4. doi:10.1016/S0014-5793(98)01483-5. PMID 9872395.
• Pestov NB, Korneenko TV, Adams G, et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization". Am. J. Physiol., Cell Physiol. 282 (4): C907–16. doi:10.1152/ajpcell.00258.2001. PMID 11880279.
• Reinhardt J, Kosch M, Lerner M, et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1". Am. J. Physiol. Renal Physiol. 283 (2): F335–43. doi:10.1152/ajprenal.00226.2001. PMID 12110518.
• Takahashi Y, Sakai H, Kuragari M, et al. (2003). "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum". Jpn. J. Physiol. 52 (3): 317–21. doi:10.2170/jjphysiol.52.317. PMID 12230809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li J, Codina J, Petroske E, et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
• Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast". Placenta. 25 (6): 505–11. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.