ANAPC7: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Anaphase-promoting complex subunit 7''' is an [[enzyme]] that in humans is encoded by the ''ANAPC7'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC7 anaphase promoting complex subunit 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51434| accessdate = }}</ref> Multiple transcript variants encoding different isoforms have been found for this gene.
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Anaphase promoting complex subunit 7
| HGNCid = 17380
| Symbol = ANAPC7
| AltSymbols =; APC7
| OMIM = 606949
| ECnumber = 
| Homologene = 10512
| MGIid = 1929711
| GeneAtlas_image1 = PBB_GE_ANAPC7_gnf1h00220_at_tn.png
| GeneAtlas_image2 = PBB_GE_ANAPC7_gnf1h00221_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ANAPC7_gnf1h07410_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005680 |text = anaphase-promoting complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51434
    | Hs_Ensembl = ENSG00000196510
    | Hs_RefseqProtein = NP_057322
    | Hs_RefseqmRNA = NM_016238
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 109296332
    | Hs_GenLoc_end = 109325815
    | Hs_Uniprot = Q9UJX3
    | Mm_EntrezGene = 56317
    | Mm_Ensembl = ENSMUSG00000029466
    | Mm_RefseqmRNA = NM_019805
    | Mm_RefseqProtein = NP_062779
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 122683098
    | Mm_GenLoc_end = 122705196
    | Mm_Uniprot = Q9WVM3
  }}
}}
'''Anaphase promoting complex subunit 7''', also known as '''ANAPC7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC7 anaphase promoting complex subunit 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51434| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
This gene encodes a [[tetratricopeptide]] repeat containing component of the [[anaphase-promoting complex]]/cyclosome (APC/C), a large [[E3 ubiquitin ligase]] that controls [[cell cycle]] progression by targeting a number of cell cycle regulators such as B-type [[cyclin]]s for 26S [[proteasome]]-mediated degradation through [[ubiquitination]]. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription [[coactivator (genetics)|coactivators]].<ref name="entrez" />
{{PBB_Summary
 
| section_title =  
==Interactions==
| summary_text = The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ANAPC7 anaphase promoting complex subunit 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51434| accessdate = }}</ref>
ANAPC7 has been shown to [[Protein-protein interaction|interact]] with [[ANAPC1]],<ref name="pmid12956947">{{cite journal | vauthors = Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM | title = TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 | journal = Curr. Biol. | volume = 13 | issue = 17 | pages = 1459–68 |date=September 2003 | pmid = 12956947 | doi = 10.1016/S0960-9822(03)00581-5 }}</ref><ref name="pmid11076961">{{cite journal | vauthors = Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM | title = Characterization of vertebrate cohesin complexes and their regulation in prophase | journal = J. Cell Biol. | volume = 151 | issue = 4 | pages = 749–62 |date=November 2000 | pmid = 11076961 | pmc = 2169443 | doi = 10.1083/jcb.151.4.749  }}</ref> [[ANAPC4]],<ref name=pmid12956947/>  [[CDC27]]<ref name=pmid12956947/><ref name="pmid10922056">{{cite journal | vauthors = Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM | title = The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 16 | pages = 8973–8 |date=August 2000 | pmid = 10922056 | pmc = 16806 | doi = 10.1073/pnas.97.16.8973 }}</ref> and [[CDC20]].<ref name=pmid12956947/><ref name="pmid18997788">{{cite journal | vauthors = Nilsson J, Yekezare M, Minshull J, Pines J | title = The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction | journal = Nat. Cell Biol. | volume = 10 | issue = 12 | pages = 1411–20 |date=December 2008 | pmid = 18997788 | pmc = 2635557 | doi = 10.1038/ncb1799 }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|ANAPC7}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Andersson B, Wentland MA, Ricafrente JY |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Yu W, Andersson B, Worley KC |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |display-authors=etal}}
*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
*{{cite journal  | vauthors=Yu H, Peters JM, King RW |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex |journal=Science |volume=279 |issue= 5354 |pages= 1219–22 |year= 1998 |pmid= 9469815 |doi=10.1126/science.279.5354.1219 |display-authors=etal}}
*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
*{{cite journal  | vauthors=Grossberger R, Gieffers C, Zachariae W |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500–7 |year= 1999 |pmid= 10318877 |doi=10.1074/jbc.274.20.14500 |display-authors=etal}}
*{{cite journal  | author=Yu H, Peters JM, King RW, ''et al.'' |title=Identification of a cullin homology region in a subunit of the anaphase-promoting complex. |journal=Science |volume=279 |issue= 5354 |pages= 1219-22 |year= 1998 |pmid= 9469815 |doi=  }}
*{{cite journal  | vauthors=Chan GK, Jablonski SA, Sudakin V |title=Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941–54 |year= 1999 |pmid= 10477750 |doi=10.1083/jcb.146.5.941 | pmc=2169490  |display-authors=etal}}
*{{cite journal  | author=Grossberger R, Gieffers C, Zachariae W, ''et al.'' |title=Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. |journal=J. Biol. Chem. |volume=274 |issue= 20 |pages= 14500-7 |year= 1999 |pmid= 10318877 |doi=  }}
*{{cite journal  | vauthors=Gieffers C, Peters BH, Kramer ER |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317–22 |year= 1999 |pmid= 10500174 |doi=10.1073/pnas.96.20.11317  | pmc=18031 |display-authors=etal}}
*{{cite journal  | author=Chan GK, Jablonski SA, Sudakin V, ''et al.'' |title=Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941-54 |year= 1999 |pmid= 10477750 |doi=  }}
*{{cite journal  | vauthors=Gmachl M, Gieffers C, Podtelejnikov AV |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973–8 |year= 2000 |pmid= 10922056 |doi=10.1073/pnas.97.16.8973  | pmc=16806 |display-authors=etal}}
*{{cite journal  | author=Gieffers C, Peters BH, Kramer ER, ''et al.'' |title=Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11317-22 |year= 1999 |pmid= 10500174 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Gmachl M, Gieffers C, Podtelejnikov AV, ''et al.'' |title=The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 16 |pages= 8973-8 |year= 2000 |pmid= 10922056 |doi=  }}
*{{cite journal  | vauthors=Vodermaier HC, Gieffers C, Maurer-Stroh S |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459–68 |year= 2004 |pmid= 12956947 |doi=10.1016/S0960-9822(03)00581-5 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Vodermaier HC, Gieffers C, Maurer-Stroh S, ''et al.'' |title=TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. |journal=Curr. Biol. |volume=13 |issue= 17 |pages= 1459-68 |year= 2004 |pmid= 12956947 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Park KH, Choi SE, Eom M, Kang Y |title=Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships |journal=Breast Cancer Res. |volume=7 |issue= 2 |pages= R238–47 |year= 2006 |pmid= 15743504 |doi= 10.1186/bcr978 | pmc=1064132 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Turnell AS, Stewart GS, Grand RJ |title=The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression |journal=Nature |volume=438 |issue= 7068 |pages= 690–5 |year= 2005 |pmid= 16319895 |doi= 10.1038/nature04151 |display-authors=etal}}
*{{cite journal  | author=Park KH, Choi SE, Eom M, Kang Y |title=Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. |journal=Breast Cancer Res. |volume=7 |issue= 2 |pages= R238-47 |year= 2006 |pmid= 15743504 |doi= 10.1186/bcr978 }}
*{{cite journal  | author=Turnell AS, Stewart GS, Grand RJ, ''et al.'' |title=The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression. |journal=Nature |volume=438 |issue= 7068 |pages= 690-5 |year= 2005 |pmid= 16319895 |doi= 10.1038/nature04151 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 18:01, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[1] Multiple transcript variants encoding different isoforms have been found for this gene.

Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[1]

Interactions

ANAPC7 has been shown to interact with ANAPC1,[2][3] ANAPC4,[2] CDC27[2][4] and CDC20.[2][5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7".
  2. ↑ 2.0 2.1 2.2 2.3 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
  3. ↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  4. ↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  5. ↑ Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.

External links

Further reading


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