ALDH8A1: Difference between revisions

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== Function ==
== Function ==


This protein belongs to the [[aldehyde dehydrogenase]] family of proteins. It plays a role in a pathway of 9-cis-[[retinoic acid]] [[biosynthesis]] in vivo. This enzyme converts 9-cis-[[retinal]] into the [[retinoid X receptor]] ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ALDH8A1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64577 | accessdate = }}</ref>
This protein belongs to the [[aldehyde dehydrogenase]] family of enzymes. It was originally thought to play a role in a pathway of 9-cis-[[retinoic acid]] [[biosynthesis]] in vivo. However, bioinformatics and experimental work has shown that it is more likely the aldehyde dehydrogenase of the [[kynurenine pathway]], oxidizing 2-aminomuconate semialdehyde to 2-aminomuconic acid.<ref>{{cite journal | vauthors = Davis I, Yang Y, Wherritt D, Liu A | title = Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism | journal = The Journal of Biological Chemistry | volume = 293 | issue = 25 | pages = 9594–9603 | date = June 2018 | pmid = 29703752 | doi = 10.1074/jbc.RA118.003320  }}</ref> Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ALDH8A1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64577 }}</ref>


== References ==
== References ==

Latest revision as of 16:12, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Aldehyde dehydrogenase 8 family, member A1 also known as ALDH8A1 is an enzyme that in humans is encoded by the ALDH8A1 gene.[1]

Function

This protein belongs to the aldehyde dehydrogenase family of enzymes. It was originally thought to play a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. However, bioinformatics and experimental work has shown that it is more likely the aldehyde dehydrogenase of the kynurenine pathway, oxidizing 2-aminomuconate semialdehyde to 2-aminomuconic acid.[2] Two transcript variants encoding distinct isoforms have been identified for this gene.[3]

References

  1. Lin M, Napoli JL (December 2000). "cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12". The Journal of Biological Chemistry. 275 (51): 40106–12. doi:10.1074/jbc.M008027200. PMID 11007799.
  2. Davis I, Yang Y, Wherritt D, Liu A (June 2018). "Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism". The Journal of Biological Chemistry. 293 (25): 9594–9603. doi:10.1074/jbc.RA118.003320. PMID 29703752.
  3. "Entrez Gene: ALDH8A1".

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.