View source for ADARB2

{{Infobox_gene}}
'''Double-stranded RNA-specific editase B2''' is an [[enzyme]] that in humans is encoded by the ''ADARB2'' [[gene]].<ref name="pmid9272162">{{cite journal | vauthors = Mittaz L, Antonarakis SE, Higuchi M, Scott HS | title = Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15 | journal = Human Genetics | volume = 100 | issue = 3–4 | pages = 398–400 | date = Sep 1997 | pmid = 9272162 | pmc =  | doi = 10.1007/s004390050523 }}</ref><ref name="pmid10836796">{{cite journal | vauthors = Chen CX, Cho DS, Wang Q, Lai F, Carter KC, Nishikura K | title = A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains | journal = RNA | volume = 6 | issue = 5 | pages = 755–67 | date = May 2000 | pmid = 10836796 | pmc = 1369955 | doi = 10.1017/S1355838200000170 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADARB2 adenosine deaminase, RNA-specific, B2 (RED2 homolog rat)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=105| accessdate = }}</ref>

== Function ==

RNA-editing deaminase-2 (RED2, or ADARB2) is a member of the double-stranded RNA (dsRNA) [[adenosine deaminase]] family of RNA-editing enzymes. Adenosine deamination of pre-mRNA results in a change in the amino acid sequence of the gene product, which differs from that predicted by the genomic DNA sequence. Other members of this family include DRADA ([[ADAR]]) and RED1 ([[ADARB1]]).<ref name="pmid9272162"/><ref name="entrez" />

Unlike ADAR1 and ADAR2, ADAR3 has demonstrated no editing ability in vitro. It has been shown to suppress [[5-HT2C]] RNA editing in vitro through a yet unknown mechanism, and may thus work as a negative regulator.<ref>{{cite journal | vauthors = Hong HQ, Lin JS, Chen L | title = Regulatory factors governing Adenosine-to-Inosine (A-to-I) RNA editing | journal = Bioscience Reports | date = Feb 2015 | pmid = 25662729 | doi = 10.1042/BSR20140190 | volume=35 | pages=1–8 | pmc=4381283}}</ref>

== References ==
{{reflist}}

==External links==
* {{UCSC gene info|ADARB2}}

== Further reading ==
{{refbegin | 2}}
* {{cite journal | vauthors = Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R | title = HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26 | journal = Advances in Experimental Medicine and Biology | volume = 421 | issue =  | pages = 185–92 | year = 1997 | pmid = 9330696 | doi = 10.1007/978-1-4757-9613-1_24 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
* {{cite journal | vauthors = Herrera C, Morimoto C, Blanco J, Mallol J, Arenzana F, Lluis C, Franco R | title = Comodulation of CXCR4 and CD26 in human lymphocytes | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 19532–9 | date = Jun 2001 | pmid = 11278278 | doi = 10.1074/jbc.M004586200 }}
* {{cite journal | vauthors = Blanco J, Valenzuela A, Herrera C, Lluís C, Hovanessian AG, Franco R | title = The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression | journal = FEBS Letters | volume = 477 | issue = 1–2 | pages = 123–8 | date = Jul 2000 | pmid = 10899322 | doi = 10.1016/S0014-5793(00)01751-8 }}
* {{cite journal | vauthors = Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R | title = Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles | journal = Journal of Immunology | volume = 158 | issue = 8 | pages = 3721–9 | date = Apr 1997 | pmid = 9103436 | doi =  }}
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = Sep 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
{{refend}}


{{gene-10-stub}}