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Revision as of 20:19, 22 December 2011

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The Class designation is used to indicate whether a therapy is recommended or not and the certainty surrounding that recommendation.

Classification of Recommendations

  • Class I: Benefit >>> Risk
  • Conditions for which there is evidence and/or general agreement that a given procedure or treatment is beneficial, useful, and effective.
  • Class II: Conditions for which there is conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of a procedure or treatment.
  • Class IIa: Benefit >> Risk
  • Weight of evidence/opinion is in favor of usefulness/efficacy.
  • Class IIb: Benefit ≥ Risk
  • Usefulness/efficacy is less well established by evidence/opinion.
  • Class III: Risk ≥ Benefit
  • Conditions for which there is evidence and/or general agreement that a procedure/treatment is not useful/effective and in some cases may be harmful.

Use the Level of Evidence designation to indicate the strength of the data associated with that recommendation.

Level of Evidence

  • Level of Evidence A: Data derived from multiple randomized clinical trials or meta-analyses.
  • Level of Evidence B: Data derived from a single randomized trial, or nonrandomized studies.
  • Level of Evidence C: Only consensus opinion of experts,case studies, or standard-of-care.

Applying Classification of Recommendations and Level of Evidence

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