(RNA-polymerase)-subunit kinase

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In enzymology, a RNA-polymerase-subunit kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + [DNA-directed RNA polymerase] <math>\rightleftharpoons</math> ADP + phospho- [DNA-directed RNA polymerase]

Thus, the two substrates of this enzyme are ATP and [DNA-directed RNA polymerase], whereas its two products are ADP and phospho- [DNA-directed RNA polymerase].

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[DNA-directed RNA polymerase] phosphotransferase. Other names in common use include CTD kinase, and STK9.


Template:Enzyme references

  • Lee JM, Greenleaf AL (1989). "A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II". Proc. Natl. Acad. Sci. U. S. A. 86: 3624&ndash, 8. PMID 2657724.

External links

The CAS registry number for this enzyme class is Template:CAS registry.

Template:Enzyme links

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Template:GO code links Template:WikiDoc Sources