]> 2026-07-31T10:04:40+00:00 WBR280 0 en Ciprofloxacin Empiric treatment of hematogenous osteomyelitis in patients with hemoglobinopathies includes coverage for Salmonella, ''E. coli'', and ''S. aureus'' species. Regimens should include ciprofloxacin and either oxacillin/nafcillin/ceftriaxone or vancomycin/linezolid depending on risk of MRSA. Linezolid Although linezolid provides adequate coverage for staphylococcal species, it does not cover ''Salmonella'' species, which are highly likely in this case given the history of thalassemia and the culture results. Ampicillin Although ampicillin provides adequate coverage for staphylococcal species, it does not cover ''Salmonella'' species, which are highly likely in this case given the history of thalassemia and the culture results. Vancomycin Although vancomycin provides adequate coverage for staphylococcal species, it does not cover ''Salmonella'' species, which are highly likely in this case given the history of thalassemia and the culture results. Clindamycin Although clindamycin provides adequate coverage for staphylococcal species, it does not cover ''Salmonella'' species, which are highly likely in this case given the history of thalassemia and the culture results. Microbiology Pharmacology Gerald Chi (Reviewed by Serge Korjian) An 8-year-old girl with a history of thalassaemia major presents to the emergency department with low-grade fever, leg pain, and malaise for the past week. Her blood pressure is 110/60 mm Hg, heart rate is 90/min, and temperature is 37.8 ᵒC (100 ᵒF). On physical examination, her anterior left shin is red, swollen, and tender to palpation. Following an extensive work-up, the diagnosis of tibial osteomyelitis is confirmed. Cultures from bone biopsies reveal gram-negative rods. Which of the following regimens is the most appropriate for the initial management of this patient? A Head and Neck Hematology Musculoskeletal/Rheumatology 2020-10-28T02:59:55Z 2459150.6249421 WBR280