]> 2026-07-31T07:51:31+00:00 WBR1004 0 en Blocking T-type Ca²⁺ channels Ethosuximide, the first line therapy for absence seizures, blocks T-type Ca²⁺ channels, decreasing membrane excitability of neurons. Decreasing influx of Na⁺ across cell membrane channels This is the most common mechanism of action by which a number of anti epileptic drugs act such as carbamazepine, phenytoin, fosphenytoin. Inhibiting GABA transaminase This is the main mechanism of action of vigabatrin. Decreasing influx of Na⁺ across cell membrane channels, and increasing the inhibitory activity of GABA This is the main mechanism of action of valproic acid. Although it is indicated for absence seizures, ethosuxamide is preferred. Antagonizing AMPA/kainate glutamate receptors Antagonism of AMPA/kainite receptors is one of the several mechanisms by which topiramate acts. Pharmacology A 5-year-old child is brought to the pediatrics clinic by concerned parents. He is reported to have occasional episodes of “staring into space” which last about 1-2 mins during which the child is unarousable even with painful stimuli but does not seem disoriented after he regains consciousness. The parents deny any jerky movements or tonic muscle spasms. Overnight monitoring with electroencephalogram demonstrates 3 Hz spike-and-slow wave complexes during one of the episodes. What is the mechanism of action of drug most commonly used to treat this condition? A Neurology 2020-10-28T02:20:30Z 2459150.5975694 WBR1004