]> 2026-07-31T07:49:56+00:00 WBR0983 0 en Acyl-CoA dehydrogenase Alpha-ketoglutarate dehydrogenase Pyruvate dehydrogenase Alpha-keto acid dehydrogenase Lactate dehydrogenase Lactate dehydrogenase catalyzes the conversion from lactate to pyruvate. Biochemistry A 6-months-old boy is brought to the physician's office for irritability and hypotonia. The mother states that she received all her prenatal vitamins and had regular follow-ups with her obstetrician. The boy was delivered abroad, and the family returned to USA 1 week prior to presentation. Her boy was normal at birth, but has had impaired psychomotor development throughout his development, which remained undiagnosed. Laboratory testing is remarkable for lactic acidosis and elevated serum alanine concentration. The physician suspects an inborn error of metabolism, and genetic studies, which demonstrate a defect in the E1 alpha gene, confirm the diagnosis. The parents are advised to maintain a strict diet with high concentrations of leucine and lysine for their child. Which enzyme deficiency is responsible for this patient's condition? C General Principles 2020-10-28T02:16:44Z 2459150.5949537 WBR0983