]> 2026-07-31T12:14:33+00:00 WBR0953 0 en 50 percent of her offspring will be affected 50 percent of her sons will be affected and 50 percent her daughters will be carriers ''' Incorrect ''' : X-linked inheritance of a single parent will result in 50 percent of her sons to be affected and 50 percent her daughters to be carriers. 25 percent of siblings will be affected and 50 percent will be carriers ''' Incorrect ''' : Autosomal recessive inheritance of each heterozygous parent has a 50 percent likelihood of transmitting the mutation, so there is a 25 percent probability that an offspring will inherit two mutations. On average, 25 percent of siblings of affected subjects will be affected, 25 percent will harbor no mutations, and 50 percent will be carriers. All her offspring will be affected ''' Incorrect ''' : All offspring of affected mothers are affected (although some may be phenotypically normal) and no offspring of affected fathers are affected in mitochondrial inheritance. All her offspring will be normal ''' Incorrect ''' : All her offspring cannot be normal because of the autosomal dominant inheritance pattern. Primary Care Office A 26 year old female presents to the office with a 6 month history of fatigue. On further review of history, she says she has been experiencing occasional palpitations for the past 1 year for which she never consulted a doctor. Her menstrual cycles are regular and she is sexually active. Her past history is otherwise insignificant and her family history is unremarkable. She does not smoke and drink. Her vitals are temperature: 36.7 C, blood pressure: 120/80 mmHg, pulse: 102/min and respiration's: 16/min. All system examinations are normal except pallor. Her laboratory values are : Hb : 7 g/dl RBC’s : 2 million/cmm WBC’s : 6000/cmm Segmented neutrophils : 60 % Bands : 2 % Eosinophils : 2 % Lymphocytes : 32 % Monocytes : 6 % MCHC : 34 % MCV : 85 fl Her peripheral smear is shown below : A Hematology 2020-10-28T02:10:36Z 2459150.5906944 WBR0953