]> 2026-07-31T07:51:10+00:00 WBR0775 0 en Anti-ribonucleoprotein antibody Anti-ribonucleoprotein is usually detected in 40% of patients with SLE. Anti-Jo1 antibody Anti-Jo1 antibodies are found in 30-40% of patients with polymyositis and to a lesser extent in patients with dermatomyositis. Anticentromere antibody Anticentromere is seen in 60-70% of patients with limited scleroderma (CREST) and around 10% of patients with the diffuse form. Anti-double stranded DNA antibody Anti-dsDNA antibodies are very specific for SLE and are involved in the pathogenesis of lupus nephritis. Anti-histone antibody Anti-histone antibodies are seen in drug induced lupus. Scleroderma defines a systemic disease that is characterized by thickening and fibrosis of the skin and internal organs to varying extents depending on the subtype. Two major forms of scleroderma exist: Limited scleroderma (CREST Syndrome) and diffuse scleroderma. CREST syndrome defines a milder form referring to a clinical pentad of '''C'''alcinosis, '''R'''aynaud's phenomenon, '''E'''sophageal dysfunction, '''S'''clerodactyly, and '''T'''elangiectasia, hence the term. The diffuse form is usually more rapidly progressive, involving large areas of skin and several internal organs. The prognosis of CREST syndrome is usually better than the diffuse form although both can be complicated by pulmonary hypertension. The etiology for both forms is unknown. Patients with CREST syndrome usually have anti-centromere antibodies while patients with diffuse scleroderma have anti-topoisomerase antibodies (anti-scl70). Treatment is mostly symptomatic.<br/> '''Educational Objective:''' CREST syndrome is the limited form of scleroderma presenting with calcinosis, Raynaud's phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia. Patients are usually is positive for anti-centromere antibody.<br/> '''References:''' UVA/UVA1 phototherapy and PUVA photochemotherapy in connective tissue diseases and related disorders: a research based review, BMC Dermatology 2004, 4:11. doi:10.1186/1471-5945-4-11 '''(Image)'''<br> Gabrielli A, Avvedimento EV, Krieg T. Scleroderma. N Engl J Med. 2009;360(19):1989-2003. Pathophysiology C Gastrointestinal Musculoskeletal/Rheumatology 2020-10-28T01:40:10Z 2459150.5695602 WBR0775