]> 2026-07-31T07:51:34+00:00 WBR0656 0 en Giant cell arteritis Giant cell arteritis or temporal arteritis is medium to large vessel vasculitis that predominantly affects the branches of the external carotid artery. Features include jaw pain, ocular disturbances and an elevated ESR. Thromboangiitis obliterans Thromboangiitis obliterans or Buerger’s disease is a small and medium vessel vasculitis that affects the hands and feet. It is strongly associated with smoking. Kawasaki syndrome Kawasaki disease is a medium-sized vasculitis classically observed in children under five years of age. It is characterized by conjunctival and oral erythema (red-strawberry tongue), fever, erythema and edema of the palms and soles, generalized rash, and cervical lymph node swelling. Polyarteritis nodosa Polyarteritis nodosa (PAN) is a small and medium-size vasculitis that affects the kidneys, heart, and GI tract. Approximately 25% of patients with PAN have positive a hepatitis B serum antigen. Takayasu’s arteritis Takayasu’s arteritis or pulseless disease, is a form of large vessel granulomatous vasculitis with massive intimal fibrosis and vascular narrowing, affecting often young or middle-aged women usually of Asian descent. Polyarteritis nodosa (PAN) is a vasculitis that mainly affects the small and medium-sized arteries, particularly the at the level of the kidneys, heart, and GI tract. Classical symptoms are non-specific and include fever, malaise, anorexia, weight loss, and myalgias. Physical examination is often remarkable for soft tissue edema, rashes (livedo relicularis; lace like rash shown in this patient), petechiae, and ulcerations. Depending on the involved system, manifestations include numbness and paresthesias, strokes, seizures, renal insufficiency, myocardial infarction or pericarditis. Approximately 25% of patients with PAN have positive a hepatitis B serum antigen. In fact, according to the American College of Rheumatology (ACR) diagnostic criteria, hepatitis B status is taken into consideration. Diagnosis is generally based on the clinical picture, laboratory studies (CBC, ESR, C-reactive protein, p-ANCA), and biopsy. Treatment involves the use of immunosuppressants – prednisone, cyclophosphamide and methotrexate.<br/> '''Educational Objective:''' Polyarteritis nodosa is a vasculitis involving the small and medium sized arteries, particularly the renal, cardiac, and gastrointestinal tract vessels. One of the classical features is the characteristic lace-like rash known as livedo reticularis. PAN is associated with hepatitis B infection.<br/> '''References:''' Ahmed S, Kitchen J, Hamilton S, Brett F, Kane D. A case of polyarteritis nodosa limited to the right calf muscles, fascia, and skin: a case report. J Med Case Rep. 2011;5:450.'''(Image)''' Pathology D Musculoskeletal/Rheumatology 2020-10-28T01:20:42Z 2459150.5560417 WBR0656