]> 2026-07-31T07:52:20+00:00 WBR0644 0 en A This step refers to the hydroxylation of proline and lysine residues mediated by Vitamin C. Scurvy would lead to a defect in this phase of collagen synthesis. B This step refers to glycosylation of specific residues in the collagen chain. It is not affected by vitamin C deficiency. C This step refers to collagen triple helix (procollagen) formation. It is defective in osteogenesis imperfecta. It is not affected by vitamin C deficiency. D This step refers to the cleavage of the terminal regions of procollagen. It is not affected by vitamin C deficiency. E This refers to collagen cross-linking via lysyl-oxidase (requires copper). This step is defective in Ehlers-Danlos disease. It is not affected by vitamin C deficiency. Scurvy is a relatively rare disease occuring in patients with severe vitamin C deficiency. As vitamin C is essential for the hydroxylation of proline and lysine residues during collagen synthesis, its deficiency leads signs of collagen abnormality. Patients initially complain of nonspecific malaise and fatigue that progresses to bony pain and dyspnea. Physical exam reveals multiple bruises compatible with a decrease in collagen synthesis in the skin. Other signs include swollen gums, poor wound healing, and anemia. Scurvy is usually seen only in patients with very poor nutrition since vitamin C is redundantly present in most diets. Patients at risk for scurvy include those who are elderly or alcoholic, those with chronic malnutrition, and men living alone, termed "widower scurvy". Treatment is usually restricted to vitamin C supplementation and supportive care.<br/> '''Educational Objective:''' Vitamin C is important in the hydroxylation of proline and lysine residues during collagen synthesis. Vitamin C deficiency lead to scurvy characterized by ecchymoses, swollen gums, and poor wound healing.<br/> '''References:''' Kumar V, Abbas AK, Fausto N, Aster JC. Environmental and nutritional diseases. In: Kumar V, Abbas AK, Fausto N, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia, PA: Elsevier Saunders; 2009:chap 9. Biochemistry A Dermatology General Principles 2020-10-28T01:18:24Z 2459150.5544444 WBR0644