]> 2026-07-31T10:04:44+00:00 WBR0643 0 en Block peptide bond formation by inhibiting peptidyltransferase This is the mechanism of action of clindamycin and chloramphenicol. Inhibit protein synthesis by inhibiting translocation of growing peptide This is the mechanism of action of macrolides. Inhibit tRNA binding to ribosome This is the mechanism of action of tetracyclines. Interfere with cell wall synthesis by blocking cross-linking This is the mechanism of action of all penicillins including carbapenems like imipenem. Interferes with cell membrane leading to postassium leak and depolarization. This is the mechanism of action of daptomycin used in MRSA infections. Pharmacology A 68-year-old woman with past history of Parkinson's disease presents to the emergency department for 12 hours of high grade fever and several episodes of chills. On admission the patient's pulse is 121/min, her blood pressure is 98/66 mm Hg, and temperature is 39.5 ᵒC (103 ᵒF). You draw 2 sets of blood cultures and initiate broad spectrum coverage with vancomycin and piperacillin/tazobactam. Two days later, the patient does not seem be improving and blood culture results reveal gram negative rods resistant to piperacillin/tazobactam. You decide to switch the patient to another antibiotic that covers gram-negative rods. After less than 24 hours on the new medication, the patient experiences a tonic-clonic seizure lasting 4 minutes and requiring sedation. What is the mechanism of action of the drug used in this patient? D Infectious Disease 2020-10-28T01:18:14Z 2459150.5543287 WBR0643