]> 2026-07-31T07:51:57+00:00 WBR0642 0 en RNA methylation inhibitors Inhibition of RNA methylation can, in theory, help decrease resistance to macrolides since it targets the main resistance mechanism. Drug acetylation inhibitors Inhibition of acetylation targets the main mechanism of aminoglycoside resistance rather than that of macrolides. Beta-lactamase inhibitors Beta-lactamase inhibitors like tazobactam, clavulanic acid, and sulbactam are used with penicillin antibiotics to inhibit destruction of the beta-lactam ring by beta-lactamase producing bacteria. Drug efflux pump blockers Although drug efflux can be seen as a mechanism of resistance to macrolides, it is minor compared to rRNA methylation. Drug adenylation inhibitors Drug adenylation is also a form of enzymatic modification seen in resistance to aminoglycosides not in macrolides. Microbiology Pharmacology A pharmaceutical company is manufacturing a novel antibiotic to overcome increasing resistance to macrolides. Its rationale is to create an agent that would be co-administered with azithromycin to counteract the mechanism by which bacteria become resistant to this antibiotic. Which of the following agents would be appropriate to investigate for this purpose? A Infectious Disease 2020-10-28T01:18:04Z 2459150.554213 WBR0642