]> 2026-07-31T12:14:25+00:00 WBR0633 0 en Sodium Stibogluconate Sodium stibogluconate is the treatment of choice for leishmaniasis. It is not associated with myelosuppression. Common side effects are phlebotoxicity and pancreatitis. Suramin/Melarsoprol Suramin and melarsoprol are used in the treatment of ''Trypanosoma brucei'', the causative agent of African sleeping disease. The combination does not cause myelosuppression. Common side effects include arsenic toxicity since melarsoprol is an organic compound of arsenic. Nifurtimox Nifurtimox is the treatment of choice for ''Trypanosoma cruzi'', the causative agent of Chagas disease. It is not associated with myelosuppresion. A common side effect is anorexia seen in approximately 10% of patients and sometimes leading to discontinuation of therapy. Pyrimethamine Pyrimethamine is the treatment of choice combined with sulfadiazine for toxoplasmosis. It causes myelosuppression that can be avoided by administering leucovorin or folinic acid. Methotrexate Methotrexate is a chemotherapeutic agent that inhibits DHFR and causes myelosuppresion salvageable through leucovorin administration. However, methotrexate is not used in the treatment of protozoal infection. Microbiology Pharmacology A 59-year-old woman, receiving chronic prednisone therapy for giant cell arteritis, is referred to an infectious disease specialist for 3 weeks of fatigue, sore throat, and generalized lymphadenopathy with recent onset blindness in her left eye. The patient is diagnosed with a protozoal illness and the physician decides to initiate therapy. He explains to the patient that the drug he intends to use works by a similar mechanism to a chemotherapeutic agent that causes bone marrow suppression. He reassures the patient that much like the chemotherapeutic agent, if this medication were to affect her, addition of folinic acid to her treatment would correct the bone marrow effects. Which of the following drugs is the physician prescribing to this patient? D Infectious Disease 2020-10-28T01:15:47Z 2459150.5526273 WBR0633