]> 2026-07-31T07:52:14+00:00 WBR0611 0 en Reduced stimulation of the direct pathway via D1 receptors Reduced stimulation of the indirect pathway via D1 receptors Reduced stimulation of the direct pathway via D2 receptors The activity of the direct pathway is reduced due to a reduced release of D1, which normally bind to D1 receptors of the striatum. Reduced inhibition of the direct pathway via D1 receptors Depletion of dopamine results in reduced inhibition of the indirect pathway via D2 receptors. Greater inhibition of the indirect pathway via D2 receptors In Parkinson's disease, depletion of dopamine results in a reduced inhibition of the indirect pathway via D2 receptors. Pathophysiology A 62-year-old man presents with complaints of a tremor in both hands. The tremor initially started in his right hand and has recently progressed over the past 4 weeks to involve his lips and his left hand. The patient also reports the tremor intensity decreases when he intentionally moves his hands, and it disappears when he sleeps. Physical examination is remarkable for a resting tremor, bradykinesia, rigidity, and shuffling gait. Which of the following is the most likely pathological mechanism responsible for this patient’s condition? A Neurology 2020-10-28T01:09:59Z 2459150.5485995 WBR0611