]> 2026-07-31T07:52:06+00:00 WBR0555 0 en Synthesis of prostacylin HDL may have a role in the increase of blood flow in patients with endothelial dysfunctions. This is carried out by its effect on vasodilation and prostacyclin synthesis. However, the anti-atherogenic properties of HDL-C are not derived from its association with prostacyclin synthesis. Caspase 3 activity Caspase 3 initiates apoptosis (programmed cell death) in cells. HDL, through its effect on caspase 3, prevents apoptosis in cells. It also reduces the generation of reactive oxygen species (ROS). Protein C and S activity HDL functions in preventing thrombus formation in the arteries through an effect on platelet activation and aggregation, which results in increased protein C&S activity, fibrinolysis, and endothelial tissue factor expression. Free cholesterol efflux from cells Insulin secretion and sensitivity HDL increases insulin secretion through AMP-activated protein kinase in skeletal muscle, thus, mediating glucose metabolism especially among patients with type 2 diabetes. Biochemistry The "HDL hypothesis" suggests that high density lipoprotein-cholesterol (HDL-C) is inversely associated with atherosclerosis, and HDL-C has a protective role against cardiovascular disease. What is the main mechanism involved in the anti-atherogenic properties of HDL-C? D Cardiology 2020-10-28T00:56:57Z 2459150.5395486 WBR0555