]> 2026-07-31T07:51:54+00:00 WBR0531 0 en Defective bone mineralization Normal mineralization with low bone mass Abundant mineralization of the periosteum Abnormal bone remodeling '''Correct'''-Abnormal bone remodeling is the primary defect where excessive resorption of bone due to excess osteoclastic activity is followed by replacement of normal marrow with dense, trabecular and disorganized bone due to activation of osteoblastic activity in Pagets disease. Defective bone and cartilage mineralization Internal medicine Vendhan Ramanujam A 74 year old male complaining of hip pain arrives at his physicians office. He also complaints of headache, hearing loss, and tinnitus. On physical exam the skull appears to be enlarged, with prominent superficial veins. There is marked kyphosis, and the bones of the leg appear to be deformed. Lab tests reveal an elevated plasma alkaline phosphatase level. A skull x-ray shows sharply demarcated lucencies in the frontal, parietal, and occipital bones. X-rays of the hip show thickening of the pelvic brim. Which one of the following is the most likely mechanism of the patient’s condition? D Endocrine Musculoskeletal/Rheumatology 2020-10-28T00:52:29Z 2459150.5364468 WBR0531