]> 2026-07-31T07:53:15+00:00 WBR0421 0 en Increased hepatocyte production of LDL-C LDL-receptor overexpression LDL receptor over-expression occurs following initiation of statin therapy secondary to decreased production of cholesterol by inhibition of HMG-CoA reductase. Deficiency of high density lipoprotein-cholesterol (HDL-C) Deficiency of LDL receptors on hepatocyte plasma membrane Deficiency of lipoprotein lipase (LPL) Deficiency of lipoprotein lipase (LPL) is type I dyslipidemia, called hyperchylomicronemia, which is characterized by elevated concentration of circulating chylomicrons that result in high concentration of triglycerides and cholesterol. Although eruptive xanthoma may be present in hyperchylomicronemia, a classic complication of hyperchylomicronemia is usually recurrent pancreatitis (due to hypertriglyceridemia), not myocardial infarction. Biochemistry A 38-year-old woman is brought to the emergency department with complaints of chest pain and shortness of breath at rest. She describes her pain as a crushing sensation in the middle of her chest that radiates to her left arm and is associated with nausea and cold sweats. The patient receives daily atorvastatin for hypercholesterolemia. She reports that multiple members of her family died at a young age from cardiovascular disease. On physical examination, the physician notes xanthomas on the Achilles tendon and arcus senilis corneae on the outer margin of the iris. In the ED, her temperature is 37.0 °C (98.6 °F), heart rate is 112/min, and blood pressure is 148/84 mmHg. An electrocardiogram (ECG) reveals ST-segment elevation in the anterior leads. Her lab work-up is remarkable for elevation of troponin I and low-density lipoprotein-cholesterol (LDL-C) concentration of 680 mg/dL. The physician suspects that the patient's condition may be caused by an inherited disease. Which of the following explains the pathogenesis of this patient’s inherited disease? D Vascular 2020-10-28T00:30:28Z 2459150.5211574 WBR0421