]> 2026-07-31T07:51:07+00:00 WBR0405 0 en Amyloid light-chain (AL) Amyloid light-chain (AL) amyloidosis is due to deposition of Ig light chains. It is commonly associated with multiple myeloma. β2-microglobulin β2-microglobulin deposition in patients on hemodialysis causes symptoms of entrapment neuropathy, such as carpal tunnel syndrome. Amylin Amylin or Islet Amyloid Polypeptide (IAPP) is produced in the beta cells of the pancreas. Amylin amyloidosis is associated with diabetes mellitus. A-Cal A-Cal protein from calcitonin is seen in patients with medullary thyroid cancer. β-Amyloid β-Amyloid is the main component of amyloid plaques associated with Alzheimer’s disease. Pathology A 67-year-old African-American woman with history of end-stage renal disease on hemodialysis presents to the physician with right wrist pain. The patient explains that she has tingling and burning sensation in the right hand along the thumb, index, and middle part of the fourth finger. The symptoms also seem to worsen at night, making it difficult for her to fall asleep. On physical examination, the patient has asymmetric weakness of thumb adduction with thenar atrophy. Tinel's sign and Phalen's maneuver are both positive. Accumulation of which product is most likely to be present in this patient’s condition? B Renal 2020-10-28T00:27:58Z 2459150.5194213 WBR0405