]> 2026-07-31T07:52:12+00:00 WBR0323 0 en Methylation Methylation hinders transcription at the level of chromatin templates. Methylation "mutes" chromatin. Phosphorylation Phosphorylation does not make the chromatin transcriptionally active. Acetylation See explanation. Oxidation Oxidation does not make the chromatin transcriptionally active. Dehydrogenation Dehydrogenation does not make the chromatin transcriptionally active. Acetylation of core histones, such as H2A, H2B, H3, and H4, plays a major role in the regulation of transcription in eukaryotic cells. The acetylation of lysine residues at the tails of histones neutralizes its positively charge and decreases its affinity for DNA. Consequently, the alteration of nucleosomal conformation facilitates the transcription at the level of chromatin templates.<br/> '''Educational Objective:''' Histone acetylation is crucial in the regulation of eukaryotic transcriptional activity.<br/> '''References:''' Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Dev. 1998;12:599-606. Genetics A researcher, studying the regulation of transcription in mice, shows that core histones undergo molecular changes at particular lysine residues, in order to neutralize their positively charged tail and to decrease their affinity for DNA. These changes enable regulatory proteins to access chromatin templates, which are required for transcription. Which of the following molecular changes is most likely to impact the histones in the researcher's observations? C General Principles 2020-10-28T00:11:17Z 2459150.5078357 WBR0323