]> 2026-07-31T07:51:12+00:00 WBR0283 0 en Segmental sclerosis and hyalinosis Diffuse capillary and glomerular basement membrane thickening Diffuse capillary and glomerular basement membrane thickening are findings observed in membranous nephropathy (MN). MN is a slowly progressive kidney disease prevalent among Caucasians between 30 and 50 years of age. Normal glomeruli A renal biopsy of minimal change disease typically shows no abnormalities on light microscopy. In contrast, electron microscopy shows effacement (fusion) of podocytes, which are visceral epithelial cells, with slit-pore membrane obliteration between podocyte foot processes. Enlarged, hypercellular glomeruli with proliferation of mesangial and endothelial cells “Wire looping” of capillaries Pathology A 5-year-old boy is brought to the emergency department (ED) by his mother. She reports that her boy has generalized swelling with decreased urine output, and she is concerned his condition is serious. She explains that 3 days ago, he had a mild swelling around the eyes, but soon his condition worsened and involved the rest of his body. The boy does not report any obvious exacerbating or alleviating factor. The patient has no past medical history and no family history for chronic diseases. Upon further questioning, the mother recalls that the patient was stung by a bee ten days ago. In the ED, the patient's temperature is 36.7 °C (98 °F), his blood pressure 110/72 mmHg, and his heart rate is 82/min. Physical examination is remarkable for generalized pitting edema and a bee sting mark in the left upper extremity. Chest x-ray is remarkable for pleural effusion. 24-hour urine collection demonstrates oval fat bodies and profound proteinuria. The physician suspects the patient's condition is caused by a renal disease. On renal biopsy, which of the following findings on light microscopy is consistent with this patient's diagnosis? C Renal 2020-10-28T00:02:51Z 2459150.5019792 WBR0283