]> 2026-07-31T07:52:09+00:00 WBR0277 0 en ''CDKN2A'' The ''CDKN2A'' tumor suppressor gene encodes cyclin-dependent kinase inhibitor 2A. ''CDKN2A'' mutations are associated with familial melanoma. ''RB'' gene ''RB'' gene mutations are implicated in the tumorigenesis of osteosarcoma and retinoblastoma. ''FLCN'' gene The ''FLCN'' gene encodes the folliculin protein, so named for the benign hair-follicle tumors that arise in Birt-Hogg Dubé patients who harbor a germline mutation of the FLCN gene. Folliculin is thought to negatively regulate mTOR signaling in the absence of amino acids. When folliculin is absent, mTOR activity is upregulated and benign skin lesions are formed. As of 2015, FLCN is not high-yield for USMLE Step 1. ''ABL'' gene ''RET'' gene Genetics Pathology An 17-year-old man presents to the physician's office with complaints of bone pain and swelling over the right leg just above the knee. He has progressively lost weight over the past 2 months. His medical history indicates that he was treated for eye cancer as an infant. Which of the following genes is most likely responsible for this patient's condition? B Oncology 2020-10-28T00:02:01Z 2459150.5014005 WBR0277