]> 2026-07-31T07:52:05+00:00 WBR0252 0 en Inhibits ergosterol synthesis Azoles, such as fluconazole, inhibit fungal ergosterol synthesis by blocking the conversion from lanosterol to ergosterol. Fluconazole is prescribed for vaginal candidiasis, which is in the differential diagnosis of bacterial vaginosis. Vaginal candidiasis is caused by the fungus ''Candida albicans''. It manifests as vaginal inflammation with pruritus, along with the presence of a thick, cottage-cheese, white discharge that typically has no odor. Vaginal pH is typically between 4 and 4.5, and vaginal smear shows pseudohyphae. Binds ergosterol and forms membrane pores that leak electrolytes Amphotericin B binds ergosterol and forms membrane pores that leak electrolytes. Inhibits dihydrofolate reductase Trimethoprim is a bacteriostatic agent that inhibits bacterial dihydrofolate reductase. Forms free radical toxic metabolites Metronidazole forms free radical toxic metabolites that cause DNA injury in the bacterial cell. Metronidazole is the first line antimicrobial therapy to treat bacterial vaginosis. Inhibits DNA gyrase Fluoroquinolones inhibit DNA gyrase (topoisomerase II) and topoisomerase IV. Pharmacology A 28-year-old woman presents to the physician's office with complaints of vaginal odor and discharge. A thin, homogeneous, greyish-white fluid that is adherent to the vaginal mucosa is observed on physical examination. The labia, introitus, cervix, and cervical discharge appear normal. Microscopic examination of the discharge demonstrates a pH = 5 and clue cells. The physician decides to prescribe an antimicrobial agent to treat this patient's condition. What is the mechanism of action of the prescribed antimicrobial agent? D Genitourinary 2020-10-27T23:55:04Z 2459150.4965741 WBR0252