]> 2026-07-31T07:28:20+00:00 WBR0164 0 en Inhibits DNA and RNA synthesis by cross-linking DNA strands and causing strand breaks Inhibits DNA-dependent RNA polymerase by intercalating between cytosine and guanine nucleotides in DNA Hyperstabilizes microtubules and inhibits the disassembly of the mitotic spindle Binds to the microtubular proteins of the mitotic spindle and results in microtubule crystallization Stimulates microtubule minus-end detachment by producing microtubule fragments Pharmacology A 3-year-old boy is brought to the pediatrician by his parents after they noticed blood in the child’s urine. Physical examination is remarkable for a palpable left flank mass. Biopsy of the mass reveals a mixed population of tubules, small round blue cells, and stroma. The child undergoes left nephrectomy and is placed on a course of adjuvant chemotherapy. Two weeks after the administration of chemotherapy, the child complains of dizziness, has trouble walking, and displays difficulty in dorsiflexion of both feet. What is the mechanism of action of the drugs most likely responsible for this patient's symptoms? E Oncology Renal 2020-10-27T23:33:27Z 2459150.4815625 WBR0164