]> 2026-07-31T07:28:15+00:00 WBR0155 0 en Neurofibrillary tangles Neurofibrillary tangles are abnormal aggregates of proteins within neurons of patients with Alzheimer's disease. Patient’s with Down syndrome have a high risk of developing Alzheimer’s disease at an early age due to increased gene dosage of the amyloid precursor protein (APP) on chromosome 21. Pick bodies Negri bodies Lewy bodies Spongioform changes Pathology A 41-year-old man with Down syndrome is brought to the family's physician for cognitive decline. The family reports that the patient’s memory has been deteriorating for the past year. He cannot recall the names of his brothers and sisters and often has difficulty finding words. He is unable to find his way back home and gets lost when a member of his family does not assist him. Which of the following neuropathologic changes is most likely present in this patient? A Neurology 2020-10-27T23:31:28Z 2459150.4801852 WBR0155