]> 2026-07-31T09:38:58+00:00 WBR0065 0 en Familial retinoblastoma Familial retinoblastoma is caused by mutations in the ''RB1'' gene that affect the Rb protein. HPV infection causes cervical cell dysplasia by expressing the E7 protein that sequesters and tags the ''RB1'' gene for degradation. Hereditary non-polyposis colorectal cancer (HNPCC) HPNCC is associated with germline mutations in several genes, such as ''MSH2'', ''MSH6'', and ''MLH1'' genes. Neurofibromatosis type I Hereditary breast-ovarian cancer syndrome Hereditary breast-ovarian cancer syndrome (HBOC) is caused by mutations in the ''BRCA1'' and ''BRCA2'' genes. Female patients with these mutations have a 40%-80% lifetime risk of breast cancer and an 11%-40% lifetime risk of ovarian cancer. Cowden’s sydrome Genetics William J Gibson (Reviewed by Yazan Daaboul) A 32-year-old woman is contacted regarding an abnormal pap smear on her most recent annual screening exam. The smear shows dysplasia of squamous cells from the surface of the cervix. The degree of dysplasia is then deemed cervical intraepithelial neoplasia grade-1 (CIN-I). The molecular mechanism of oncogenesis of the causal organism is similar to the defect underlying which disease? A Oncology 2020-10-27T23:13:29Z 2459150.4676968 WBR0065