Desirudin
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gerald Chi
Disclaimer
WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
Black Box Warning
WARNING
See full prescribing information for complete Boxed Warning.
SPINAL/EPIDURAL HEMATOMAS:
|
Overview
Desirudin is a direct thrombin inhibitor that is FDA approved for the {{{indicationType}}} of deep vein thrombosis in patients undergoing elective hip replacement surgery. There is a Black Box Warning for this drug as shown here. Common adverse reactions include hemorrhage, injection site mass, wound secretion, anemia, deep thrombophlebitis, and nausea.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
Prophylaxis of Deep Vein Thrombosis
- Dosing Information
- All patients should be evaluated for bleeding disorder risk before prophylactic administration of Iprivask.
- Initial Dosage
- In patients undergoing hip replacement surgery, the recommended dose of Iprivask is 15 mg every 12 hours administered by subcutaneous injection with the initial dose given up to 5 to 15 minutes prior to surgery, but after induction of regional block anesthesia, if used. Up to 12 days administration (average duration 9 to 12 days) of Iprivask has been well tolerated in controlled clinical trials.
- Dose in Renal Impairment
- Dose in Hepatic Impairment
- In the absence of clinical studies in this population, dosing recommendations cannot be made at this time.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Desirudin in adult patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Desirudin in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding FDA-Labeled Use of Desirudin in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
Condition1
- Developed by:
- Class of Recommendation:
- Strength of Evidence:
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Desirudin in pediatric patients.
Non–Guideline-Supported Use
Condition1
- Dosing Information
- Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Desirudin in pediatric patients.
Contraindications
- Condition1
Warnings
WARNING
See full prescribing information for complete Boxed Warning.
SPINAL/EPIDURAL HEMATOMAS:
|
- Description
Precautions
- Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Desirudin in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Desirudin in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Drug Interactions
- Drug
- Description
Use in Specific Populations
Pregnancy
- Pregnancy Category
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Desirudin in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Desirudin during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Desirudin with respect to nursing mothers.
Pediatric Use
There is no FDA guidance on the use of Desirudin with respect to pediatric patients.
Geriatic Use
There is no FDA guidance on the use of Desirudin with respect to geriatric patients.
Gender
There is no FDA guidance on the use of Desirudin with respect to specific gender populations.
Race
There is no FDA guidance on the use of Desirudin with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Desirudin in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Desirudin in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Desirudin in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Desirudin in patients who are immunocompromised.
Administration and Monitoring
Administration
- Oral
- Intravenous
Monitoring
There is limited information regarding Monitoring of Desirudin in the drug label.
Condition1
- Description
IV Compatibility
There is limited information regarding IV Compatibility of Desirudin in the drug label.
Overdosage
Acute Overdose
Signs and Symptoms
- Description
Management
- Description
Chronic Overdose
There is limited information regarding Chronic Overdose of Desirudin in the drug label.
Pharmacology
There is limited information regarding Desirudin Pharmacology in the drug label.
Mechanism of Action
Structure
Pharmacodynamics
There is limited information regarding Pharmacodynamics of Desirudin in the drug label.
Pharmacokinetics
There is limited information regarding Pharmacokinetics of Desirudin in the drug label.
Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Desirudin in the drug label.
Clinical Studies
There is limited information regarding Clinical Studies of Desirudin in the drug label.
Condition1
- Description
How Supplied
Storage
There is limited information regarding Desirudin Storage in the drug label.
Images
Drug Images
{{#ask: Page Name::Desirudin |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}
Package and Label Display Panel
{{#ask: Label Page::Desirudin |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}
Patient Counseling Information
There is limited information regarding Patient Counseling Information of Desirudin in the drug label.
Precautions with Alcohol
- Alcohol-Desirudin interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
- Iprivask®[1]
Look-Alike Drug Names
- N/A[2]
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
- ↑ "IPRIVASK (desirudin) kit".
- ↑ "http://www.ismp.org". External link in
|title=
(help)
{{#subobject:
|Page Name=Desirudin |Pill Name=No image.jpg |Drug Name= |Pill Ingred=|+sep=; |Pill Imprint= |Pill Dosage= |Pill Color=|+sep=; |Pill Shape= |Pill Size (mm)= |Pill Scoring= |Pill Image= |Drug Author= |NDC=
}}
{{#subobject:
|Label Page=Desirudin |Label Name=Desirudin11.png
}}
{{#subobject:
|Label Page=Desirudin |Label Name=Desirudin11.png
}}