Sandbox colesevelam

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

Synonyms / Brand Names: Welchol tablet

Overview

Colesevelam is a bile acid sequestrant administered orally. It is developed by Genzyme and marketed in the US by Daiichi Sankyo under the brand name Welchol and elsewhere by Genzyme as Cholestagel. In Canada it is marketed by Valeant as Lodalis.

Category

Bile Acid Sequestrant

Adult Indications and Dosage of Tablet

• Initial dose (not receiving a diuretic): Lotensin 10 mg PO qd

• Initial dose (concurrent diuretic use): the diuretic should be discontinued 2 to 3 days prior to beginning therapy with Lotensin, if blood pressure is not controlled with Lotensin alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 5 mg Lotensin should be used.

• Maintenance dose: Lotensin 20—40 mg PO qd or Lotensin 10—20 mg PO bid (MAX 80 mg/day)

Adult Indications and Dosage of Tablet, film coated

• Initial dose (not receiving a diuretic): Lotensin 10 mg PO qd

• Initial dose (concurrent diuretic use): the diuretic should be discontinued 2 to 3 days prior to beginning therapy with Lotensin, if blood pressure is not controlled with Lotensin alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 5 mg Lotensin should be used.

• Maintenance dose: Lotensin 20—40 mg PO qd or Lotensin 10—20 mg PO bid (MAX 80 mg/day)