BRCA screening tools
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Twinkle Singh, M.B.B.S. [2]
Overview
Ontario Family History Assessment Tool
| Risk Factor | Points |
| Breast and ovarian cancer | |
|---|---|
| Mother | 10 |
| Sibling | 7 |
| Second/third degree relative | 5 |
| Breast cancer relative | |
| Parent | 4 |
| Sibling | 3 |
| Second/third degree relative | 2 |
| Male relative | 2 |
| Breast cancer characteristics | |
| Onset at age 20-29 y | 6 |
| Onset at age 30-39 y | 4 |
| Onset at age 40-49 y | 2 |
| Premenopausal/perimenopausal | 2 |
| Bilateral/multifocal | 3 |
| Ovarian cancer relative | |
| Mother | 7 |
| Sibling | 4 |
| Second/third degree relative | 3 |
| Age at ovarian cancer onset | |
| <40 y | 6 |
| 40-60 y | 4 |
| >60 y | 2 |
| Age at prostate cancer onset | |
| <50 y | 1 |
| Age at colon cancer onset | |
| <50 y | 1 |
Patients having a total score of equal to or more than ten should be referred to genetic testing for presence of potentially harmful BRCA mutations. Lifetime risk for breast cancer doubles with a score of more than ten.[1]
References
- ↑ Gilpin CA, Carson N, Hunter AG (2000). "A preliminary validation of a family history assessment form to select women at risk for breast or ovarian cancer for referral to a genetics center". Clin Genet. 58 (4): 299–308. PMID 11076055.