Cefepime microbiology

Cefepime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefepime has a broad spectrum of in vitro activity that encompasses a wide range of Gram-positive and Gram-negative bacteria. Cefepime has a low affinity for chromosomally-encoded beta-lactamases. Cefepime is highly resistant to hydrolysis by most beta-lactamases and exhibits rapid penetration into Gram-negative bacterial cells. Within bacterial cells, the molecular targets of cefepime are the penicillin binding proteins (PBP). Cefepime has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections:

Aerobic Gram-Negative Microorganisms: Enterobacter Escherichia coli Klebsiella pneumoniae Proteus mirabilis Pseudomonas aeruginosa Aerobic Gram-Positive Microorganisms: Staphylococcus aureus (methicillin-susceptible isolates only) Streptococcus pneumoniae Streptococcus pyogenes (Lancefield’s Group A streptococci) Viridans group streptococci.