Donovanosis pathophysiology
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Donovanosis Microchapters |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]
Overview
Pathophysiology
The microorganism spreads from one host to another through contact with the open sores. Oral, vaginal or anal intercourse are high risk behaviors to engage in with someone who is infected.
Microscopic Pathology
The proper clinical designation for donovanosis is granuloma inguinale.[1] Granuloma is a nodular type of inflammatory reaction, and inguinale refers to the inguinal region, which is commonly involved in this infection. The disease is commonly known as donovanosis, after the Donovan Bodies which are a diagnostic sign. Discovered by a researcher named Donovan, these intracellular inclusions represent bacteria that have been engulfed by scavenger cells called mononuclear phagocytes or histiocytes.
References
- ↑ Murray P. et al. (2005), Medical Microbiology, fifth ed., Elsevier Mosby, p. 336.