Gigantism (patient information)

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Gigantism

Overview

What are the symptoms?

What are the causes?

Diagnosis

When to seek urgent medical care?

Treatment options

What to expect (Outlook/Prognosis)?

Possible complications

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Overview

Gigantism is abnormally large growth due to an excess of growth hormone during childhood, before the bone growth plates have closed.

What are the symptoms of Gigantism?

The child will grow in height, as well as in the muscles and organs. This excessive growth makes the child extremely large for his or her age.

Other symptoms include:

What causes Gigantism?

The most common cause of too much growth hormone release is a noncancerous (benign) tumor of the pituitary gland. Other causes include:

If excess growth hormone occurs after normal bone growth has stopped, the condition is known as acromegaly.

Gigantism is very rare.

Who is at highest risk?

Diagnosis

Damage to the pituitary may lead to low levels of other hormones, including:

When to seek urgent medical care?

Call your health care provider if your child has signs of excessive growth.

Treatment options

In pituitary tumors with well-defined borders, surgery is the treatment of choice and can cure many cases.

For situations in which surgery cannot completely remove the tumor, medication is the treatment of choice. The most effective medications are somatostatin analogs (such as octreotide or long-acting lanreotide), which reduce growth hormone release.

Dopamine agonists (bromocriptine mesylate, cabergoline) have also been used to reduce growth hormone release, but these are generally less effective. Pegvisomant, a medication that blocks the effect of growth hormone, may be used.

Radiation therapy has also been used to bring growth hormone levels to normal. However, it can take 5 - 10 years for the full effects to be seen and this almost always leads to low levels of other pituitary hormones.

Radiation has also been linked to learning disabilities, obesity, and emotional changes in children. Most experts will use radiation only if surgery and medication fail.

Where to find medical care for Gigantism?

Prevention

What to expect (Outlook/Prognosis)?

Pituitary surgery is usually successful in limiting growth hormone production.

Possible complications

Surgery and radiation can both lead to low levels of other pituitary hormones, which can cause:

Sources