U2 small nuclear RNA auxiliary factor 1

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U2 small nuclear RNA auxiliary factor 1
File:PBB Protein U2AF1 image.jpg
PDB rendering based on 1jmt.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols U2AF1 ; DKFZp313J1712; FP793; RN; RNU2AF1; U2AF35; U2AFBP
External IDs Template:OMIM5 Template:MGI HomoloGene: 14345
RNA expression pattern
File:PBB GE U2AF1 202858 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

U2 small nuclear RNA auxiliary factor 1, also known as U2AF1, is a human gene.[1]

This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1".

Further reading

  • Zhang M, Zamore PD, Carmo-Fonseca M; et al. (1992). "Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8769–73. PMID 1388271.
  • Zamore PD, Green MR (1991). "Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution". EMBO J. 10 (1): 207–14. PMID 1824937.
  • Kalcheva I, Plass C, Sait S; et al. (1994). "Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5". Cytogenet. Cell Genet. 68 (1–2): 19–24. PMID 7956352.
  • Wu JY, Maniatis T (1994). "Specific interactions between proteins implicated in splice site selection and regulated alternative splicing". Cell. 75 (6): 1061–70. PMID 8261509.
  • Zuo P, Maniatis T (1996). "The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing". Genes Dev. 10 (11): 1356–68. PMID 8647433.
  • Lalioti MD, Gos A, Green MR; et al. (1997). "The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3". Genomics. 33 (2): 298–300. doi:10.1006/geno.1996.0196. PMID 8660980.
  • Hong W, Bennett M, Xiao Y; et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. PMID 9016565.
  • Tronchère H, Wang J, Fu XD (1997). "A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA". Nature. 388 (6640): 397–400. doi:10.1038/41137. PMID 9237760.
  • Wang HY, Lin W, Dyck JA; et al. (1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. PMID 9472028.
  • Rudner DZ, Kanaar R, Breger KS, Rio DC (1998). "Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo". Mol. Cell. Biol. 18 (4): 1765–73. PMID 9528748.
  • Lallena MJ, Martínez C, Valcárcel J, Correas I (1998). "Functional association of nuclear protein 4.1 with pre-mRNA splicing factors". J. Cell. Sci. 111 ( Pt 14): 1963–71. PMID 9645944.
  • Gozani O, Potashkin J, Reed R (1998). "A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site". Mol. Cell. Biol. 18 (8): 4752–60. PMID 9671485.
  • Neubauer G, King A, Rappsilber J; et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
  • Xiao SH, Manley JL (1999). "Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2". EMBO J. 17 (21): 6359–67. doi:10.1093/emboj/17.21.6359. PMID 9799243.
  • Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
  • de Vries H, Rüegsegger U, Hübner W; et al. (2000). "Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors". EMBO J. 19 (21): 5895–904. doi:10.1093/emboj/19.21.5895. PMID 11060040.
  • Gama-Carvalho M, Carvalho MP, Kehlenbach A; et al. (2001). "Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF". J. Biol. Chem. 276 (16): 13104–12. doi:10.1074/jbc.M008759200. PMID 11118443.
  • Adams DJ, van der Weyden L, Mayeda A; et al. (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. PMID 11448987.
  • Will CL, Schneider C, MacMillan AM; et al. (2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site". EMBO J. 20 (16): 4536–46. doi:10.1093/emboj/20.16.4536. PMID 11500380.
  • Nesic D, Krämer A (2001). "Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation". Mol. Cell. Biol. 21 (19): 6406–17. PMID 11533230.

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