Cirrhosis surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Surgery

Transplantation

If complications cannot be controlled or when the liver ceases functioning, liver transplantation is necessary. Survival from liver transplantation has been improving over the 1990s, and the five-year survival rate is now around 80%, depending largely on the severity of disease and other medical problems in the recipient.^[1] In the United States, the MELD score ^[2] is used to prioritize patients for transplantation. Transplantation necessitates the use of immune suppressants (ciclosporin or tacrolimus).

Prevalence

A recent study was completed between 1995 and 2006 that sought out to determine if there was a correlation between ursodeoxycholic acid (UDCA) and a decreases in liver transplantations for treating primary biliary cirrhosis.^[3] In 2006 the results showed that over a ten year period the amount of liver transplantations needed for people with cirrhosis decreased by an average of 5.4 cases per year.^[3] Although no causal relationship has been confirmed, this study has shown strong support to the notion that UDCA use has decreased the need for liver transplantation in patients presenting with primary biliary cirrhosis.^[3]

References

↑ liver transplant outlook and survival rates
↑ Cosby RL, Yee B, Schrier RW (1989). "New classification with prognostic value in cirrhotic patients". Mineral and electrolyte metabolism. 15 (5): 261–6. PMID 2682175.
↑ ^3.0 ^3.1 ^3.2 Lee J, Belanger A, Doucette JT, Stanca C, Friedman S, Bach N (2007). "Transplantation trends in primary biliary cirrhosis". Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 5 (11): 1313–5. doi:10.1016/j.cgh.2007.07.015. PMID 17900996. Retrieved 2012-09-06. Unknown parameter |month= ignored (help)

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[1] ver transplant outlook and survival rates

[pmid2682175-2] Cosby RL, Yee B, Schrier RW (1989). "New classification with prognostic value in cirrhotic patients". Mineral and electrolyte metabolism. 15 (5): 261–6. PMID 2682175.

[pmid17900996-3] 3.0 ^3.1 ^3.2 Lee J, Belanger A, Doucette JT, Stanca C, Friedman S, Bach N (2007). "Transplantation trends in primary biliary cirrhosis". Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 5 (11): 1313–5. doi:10.1016/j.cgh.2007.07.015. PMID 17900996. Retrieved 2012-09-06. Unknown parameter |month= ignored (help)

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