MKNK2

MAP kinase interacting serine/threonine kinase 2
File:PBB Protein MKNK2 image.jpg PDB rendering based on 2ac3.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2ac3​, 2ac5​, 2hw7​
Identifiers
Symbols	MKNK2 ; GPRK7; MNK2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 49674
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MKNK2 218205 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

MAP kinase interacting serine/threonine kinase 2, also known as MKNK2, is a human gene.

Further reading

• Haribabu B, Snyderman R (1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family". Proc. Natl. Acad. Sci. U.S.A. 90 (20): 9398–402. PMID 8415712.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. PMID 9155017.CS1 maint: Multiple names: authors list (link)
• Slentz-Kesler K, Moore JT, Lombard M; et al. (2001). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheper GC, Morrice NA, Kleijn M, Proud CG (2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells". Mol. Cell. Biol. 21 (3): 743–54. doi:10.1128/MCB.21.3.743-754.2001. PMID 11154262.CS1 maint: Multiple names: authors list (link)
• Knauf U, Tschopp C, Gram H (2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2". Mol. Cell. Biol. 21 (16): 5500–11. doi:10.1128/MCB.21.16.5500-5511.2001. PMID 11463832.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scheper GC, Parra JL, Wilson M; et al. (2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. 23 (16): 5692–705. PMID 12897141.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (2005). "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway". J. Virol. 79 (17): 11366–81. doi:10.1128/JVI.79.17.11366-11381.2005. PMID 16103188.CS1 maint: Multiple names: authors list (link)
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jauch R, Jäkel S, Netter C; et al. (2006). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site". Structure. 13 (10): 1559–68. doi:10.1016/j.str.2005.07.013. PMID 16216586.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang P, Wang X, Wang F; et al. (2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Sci. China, C, Life Sci. 49 (3): 265–73. PMID 16856496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)